We have Ranked, Sorted and Summarized the Latest Clinical Articles.

118F-Fluorocholine PET/CT for early response assessment in patients with metastatic castration-resistant prostate cancer treated with enzalutamideEuropean Journal of Nuclear Medicine & Molecular Imaging, July 07, 2015  Clinical Article
2Diagnostic importance of selected protein serum markers in the primary diagnostics of prostate cancerUrologia Internationalis, July 07, 2015  Clinical Article
3Age is associated with upgrading at confirmatory biopsy among men with prostate cancer treated with active surveillanceThe Journal of Urology, July 07, 2015  Clinical Article
4Immuno-based detection of extracellular vesicles in urine as diagnostic marker for prostate cancerInternational Journal of Cancer, July 07, 2015  Clinical Article
5An NKX3.1 binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancerInternational Journal of Cancer, July 07, 2015  Clinical Article
6Burden of benign prostatic hyperplasia among men in Japan: Patient-reported outcomes among those diagnosed and experiencing symptomsInternational Journal of Urology, July 07, 2015  Clinical Article
7Margin details matter: The prognostic significance of pseudocapsule invasion at the site of involved margin in prostatectomy specimensUrologic Oncology: Seminars and Original Investigations, July 07, 2015  Clinical Article
8Post-treated prostate cancer: normal findings and signs of local relapse on multiparametric magnetic resonance imagingAbdominal Imaging , July 07, 2015  Clinical Article
9Early diagnosis of bladder cancer through the detection of urinary tyrosine-phosphorylated proteinsBritish Journal of Cancer, July 07, 2015  Clinical Article
10Gout is associated with organic and psychogenic erectile dysfunctionEuropean Journal of Internal Medicine , July 07, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1New mechanism for male infertility discoveredKarolinska Institutet, July 06, 2015
2Re-engineered antibiotic shows potential for treatment of drug-resistant bacteriaSt. Jude Children's Research Hospital News, July 06, 2015
3New radiotherapy technique could target prostate cancer while reducing side-effectsInstitute of Cancer Research, July 02, 2015
4Human urine helps prevent bacteria from sticking to bladder cellsAmerican Society for Microbiology News, July 02, 2015
5Penn team identifies gene responsible for some cases of male infertilityUniversity of Pennsylvania News, July 02, 2015
6Long-term survival rates satisfactory for bladder cancer patients treated with robotic surgeryRoswell Park Cancer Institute News, June 30, 2015
7New and innovative approach for successful vaccination against Chlamydia infectionsMedical University of Vienna, June 26, 2015
8Sperm meets egg: Mystery event may play key role in fertilizationUniversity of Virginia Health System News, June 26, 2015
9A person's diet, acidity of urine may affect susceptibility to UTIsWashington University School of Medicine in St. Louis News, June 26, 2015
10Breast cancer gene signature predicts bladder cancer progressionNorris Cotton Cancer Center News, June 26, 2015

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GALNT4 predicts survival in patients with ccRCC

As reported in the Journal of Urology, N-acetylgalactosaminyltransferase 4 (GALNT4) levels are decreased in tumor specimens from patients with clear cell renal cell carcinoma (ccRCC; n=104) compared to peritumoral specimens. Decreased expression of GALNT4 is associated with poor OS (OR=3.08) and RFS (OR=2.17). Further, GALNT4 is negatively correlated with tumor size, necrosis, and TNM stage.

3-month PSA is a predictor of BCR-free survival after radical prostatectomy

As reported in the International Journal of Clinical Oncology, the 5-year biochemical recurrence (BCR)-free survival rate is significantly higher in patients with a 3-month PSA level < 0.010 ng/ml compared to patients with a 3-month PSA level between 0.010 and 100 ng/ml (92.6% vs. 57.4%). Amongst 174 men who underwent radical prostatectomy for clinically localized prostate cancer, 18.4% had a BCR and the median time to BCR was 16 months.

Chromogranin A staining as a biomarker for prostate adenocarcinoma

As reported in The Prostate, chromogranin A (CgA) staining, an indicator of neuroendocrine differentiation, is associated with decreased biochemical control, clinical failure, increased distant metastases, and decreased cause-specific survival in patients with prostate adenocarcinoma and a GS ≥ 7 (n=285). The median follow-up was 6.5 y. CgA staining was present in 31% of specimens. The 10-y distant metastases rate in specimens with <1% and >1% CgA staining was 8% and 48%, respectively. The 10-y cause-specific survival in specimens with <1% and >1% CgA staining was 95% vs. 76%, respectively.

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Clinical Pearls

Clinical Pearl from Smartest DocThe kSORT blood QPCR assay is a noninvasive tool to detect high risk of acute rejection of renal transplants.

Clinical Pearl from Smartest DocPatients receiving GnRH agonists for prostate cancer have a 30% rate of acute kidney injury at 10 years.

Clinical Pearl from Smartest DocThere is no prognostic benefit of uPSA doubling time calculation in prostate cancer after radical prostatectomy.

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