1Nanowire analysis of cancer-testis antigens as biomarkers of aggressive prostate cancerUrology  Clinical Article
2Docetaxel and prednisone with or without lenalidomide in chemotherapy-naive patients with metastatic castration-resistant prostate cancer (MAINSAIL): A randomised, double-blind, placebo-controlled phase 3 trialThe Lancet Oncology  Clinical Article
3Defining a standard set of patient-centered outcomes for men with localized prostate cancerEuropean Urology  Full Text  Clinical Article
4Neo-adjuvant hormone therapy for non-metastatic prostate cancer: A systematic review and meta-analysis of 5,194 patientsWorld Journal of Surgical Oncology  Full Text  Review Article
5Outcomes with abiraterone acetate in metastatic castration-resistant prostate cancer patients who have poor performance statusEuropean Urology  Full Text  Clinical Article
63D vs 2D laparoscopic radical prostatectomy in organ-confined prostate cancer: Comparison of operative data and pentafecta rates: A single cohort studyBMC Urology  Full Text  Clinical Article
7Rotating frame relaxation imaging of prostate cancer: Repeatability, cancer detection, and Gleason score predictionMagnetic Resonance in Medicine  Clinical Article
8Degree of preservation of the neurovascular bundles during radical prostatectomy and urinary continence 1 year after surgeryEuropean Urology  Full Text  Clinical Article
9Sodium fluorescein use during intraoperative cystoscopyObstetrics and Gynecology  Clinical Article
10Economic evaluation of diagnostic localization following biochemical prostate cancer recurrenceInternational Journal of Technology Assessment in Health Care  Clinical Article
1Healthy-looking prostate cells mask cancer-causing mutationsCancer Research UK News
2Wake Forest Baptist first in state offering new prostate treatmentWake Forest Baptist Medical Center News
3Sophisticated application of magnetic force enhances laparoscopic surgeryVanderbilt University Medical Center Research News
4Rutgers Cancer Institute of New Jersey advances understanding of surgical treatment options for genitourinary cancersRutgers Cancer Institute of New Jersey News
5Black men less willing to be investigated for prostate cancerUniversity of Exeter Medical School
6Urine test could lead to better treatment of bladder cancerUniversity of Birmingham Medical News
7Mount Sinai researchers find chemotherapy after bladder cancer surgery improved survivalThe Mount Sinai Hospital
8UCLA study could point toward better decisions for treating men with prostate cancerUCLA Health System
9Lycopene may ward off kidney cancer in older womenWayne State University School of Medicine News
10Active surveillance of intermediate-risk prostate cancer associated with decreased survivalAmerican Society of Clinical Oncology (ASCO) News

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Chromogranin A staining as a biomarker for prostate adenocarcinoma

As reported in The Prostate, chromogranin A (CgA) staining, an indicator of neuroendocrine differentiation, is associated with decreased biochemical control, clinical failure, increased distant metastases, and decreased cause-specific survival in patients with prostate adenocarcinoma and a GS ≥ 7 (n=285). The median follow-up was 6.5 y. CgA staining was present in 31% of specimens. The 10-y distant metastases rate in specimens with <1% and >1% CgA staining was 8% and 48%, respectively. The 10-y cause-specific survival in specimens with <1% and >1% CgA staining was 95% vs. 76%, respectively.

NSAID use inversely related to prostate cancer incidence and mortality

Based on a meta-analysis reported in BMC Medicine, NSAID use is associated with a decreased risk of prostate cancer (OR=0.92 [total] and 0.81 [advanced]) and prostate cancer-specific mortality (HR=0.86 [total] and 0.81 [advanced]).

Water restriction improves nocturia

As reported in the International Journal of Urology, daytime/night-time water restriction significantly improves nocturia in patients with urine production ≥ 30 mL/kg.

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Clinical Pearls

Clinical Pearl from Smartest DocOnset of depression and weight gain may promote urinary incontinence in middle-aged women.

Clinical Pearl from Smartest DocFunctional or oncologic outcomes do not differ between prostate capsule sparing and nerve sparing radical cystectomy for bladder cancer.

Clinical Pearl from Smartest DocHyperglycemia and insulin resistance increase the risk of BPH and LUTS.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List