The Latest Clinical Articles in Urology

1Defining a standard set of patient-centered outcomes for men with localized prostate cancerEuropean Urology, March 26, 2015  Full Text  Clinical Article
2Prostate cancer marker panel with single cell sensitivity in urineThe Prostate, March 26, 2015  Clinical Article
3Understanding the mechanisms of androgen deprivation resistance in prostate cancer at the molecular levelEuropean Urology, March 26, 2015  Full Text  Review Article
45α-Reductase inhibitors increase acute coronary syndrome risk in patients with benign prostate hyperplasiaJournal of Endocrinological Investigation, March 26, 2015  Full Text  Clinical Article
5Racial variation in prostate cancer upgrading and upstaging among men with low-risk clinical characteristicsEuropean Urology, March 26, 2015  Full Text  Clinical Article
6Dietary style and acid load in an Italian population of calcium kidney stone formersNutrition, Metabolism & Cardiovascular Diseases, March 26, 2015  Clinical Article
7Depression and anxiety in men with sexual dysfunction: A retrospective studyComprehensive Psychiatry, March 26, 2015  Review Article
8Micro-ribonucleic acid 29b inhibits cell proliferation and invasion and enhances cell apoptosis and chemotherapy effects of cisplatin via targeting of DNMT3b and AKT3 in prostate cancerOncoTargets and Therapy, March 26, 2015  Full Text  Clinical Article
9A comparison of the effects of morphine and sublingual desmopressin combination therapy with morphine alone in treatment of renal colic: A controlled clinical trialUrology Journal, March 26, 2015  Full Text  Clinical Article
10Center-level experience and kidney transplant outcomes in HIV-infected recipientsAmerican Journal of Transplantation, March 26, 2015  Clinical Article
1American College of Physicians joins HHS in accelerating alternative payment methods through ‘Health Care Payment Learning and Action Network’ American College of Physicians News, March 26, 2015
2Study identifies “lethal” subtype of prostate cancerUniversity of Colorado Health News, March 18, 2015
3Gene leads to malformation of the urinary tractUniversity of Bonn News, March 17, 2015
4Antibiotics found to have unexpected effects on mitochondriaEcole Polytechnique Fédérale de Lausanne News, March 17, 2015
5Geography matters: Imaging overuse seen for breast & prostate cancer in certain regions across the U.S.NYU Langone Medical Center, March 17, 2015
6Naproxen plus acid blocking drug shows promise in preventing bladder cancerUniversity of Michigan Health System, March 13, 2015
7Family history of prostate cancer raises a woman’s risk of breast cancerFred Hutchinson Cancer Research Center News, March 13, 2015

Show Me:

Water restriction improves nocturia

As reported in the International Journal of Urology, daytime/night-time water restriction significantly improves nocturia in patients with urine production ≥ 30 mL/kg.

3-month PSA is a predictor of BCR-free survival after radical prostatectomy

As reported in the International Journal of Clinical Oncology, the 5-year biochemical recurrence (BCR)-free survival rate is significantly higher in patients with a 3-month PSA level < 0.010 ng/ml compared to patients with a 3-month PSA level between 0.010 and 100 ng/ml (92.6% vs. 57.4%). Amongst 174 men who underwent radical prostatectomy for clinically localized prostate cancer, 18.4% had a BCR and the median time to BCR was 16 months.

PCA3 useful for early diagnosis of prostate cancer

Based on a meta-analysis reported in the Chinese Medical Journal, prostate cancer antigen 3 (PCA3) can be used for the early diagnosis of prostate cancer and to avoid unnecessary biopsies, with a sensitivity of 0.82, a specificity of 0.962, a positive likelihood ratio of 2.39, a negative likelihood ratio of 0.51, and a diagnostic odds ratio of 4.89.

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Clinical Pearls

Clinical Pearl from Smartest DocMMP-1 is a potential biomarker of FGFR3-targeted therapies for bladder cancer.

Clinical Pearl from Smartest DocThere is no prognostic benefit of uPSA doubling time calculation in prostate cancer after radical prostatectomy.

Clinical Pearl from Smartest DocRetrograde intrarenal surgery and miniperc are more effective against 1-2 cm radiolucent lower calyceal renal calculi.

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