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Postoperative nonconvulsive encephalopathic status: identification of a syndrome responsible for delayed progressive deterioration of neurological status after skull base surgery
Journal of Neurosurgery, 11/06/09

Al–Mefty O et al. – In this study, the authors delineate and raise the awareness of an unusual syndrome. Recognition of this syndrome is important as a cause for delayed coma after surgery. The authors stress the need for respiratory, hemodynamic, and nutritional support for these patients until recovery. The origin of this syndrome remains enigmatic and is likely to be multifactorial with a prominent pharmacological role related to anesthetic agent or medication in a setting of craniotomy that is associated with alteration of the blood–brain barrier.

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Borderline cases between benignancy and malignancy of the...