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Angiostatic factors normally restrict islet endothelial cell proliferation and migration: implications for islet transplantation
Transplant International, 11/06/09
Johansson A et al. – VEGF may attract recipient blood vessels towards intrahepatically transplanted islets, but intra–islet vascular expansion is hampered by angiostatic factors present within the islets and the islet endothelium. Inhibition of angiostatic factors early after transplantation may provide a strategy to restore the islet vascular network and improve islet graft function.
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