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Immunohistochemistry as First-line Screening for Detecting Colorectal Cancer Patients at Risk for Hereditary Nonpolyposis Colorectal Cancer Syndrome: A 2-antibody Panel May be as Predictive as a 4-antibody Panel
American Journal of Surgical Pathology , 10/29/09
Shia J et al. – The findings provide evidence that a 2–antibody panel is as effective as the current 4–antibody panel in detecting DNA mismatch repair protein abnormalities. Such a cost–effective approach carries significant implication, as immunohistochemistry is being widely used as first–line screening for HNPCC.
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