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Overlapping Features Between Dedifferentiated Liposarcoma and Undifferentiated High-Grade Pleomorphic Sarcoma
American Journal of Surgical Pathology , 10/28/09
Chung L et al. – The results demonstrate that (1) the lipogenic tumor markers CDK4 and MDM2 can be used as surrogate immunohistochemical markers for the diagnosis of malignant lipomatous tumors with high sensitivity; (2) approximately 26% of retroperitoneal/thigh UHGPS cases that were positive for PPAR–gamma, CDK4, or MDM2 by immunohistochemistry showed characteristic CDK4 and MDM2 gene amplification, suggesting that a subset of UHGPS cases represent DDL despite lacking histologic evidence of lipoblasts.
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