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Lemperle G et al. – ArteFill is the first permanent injectable approved in 2006 by the FDA for nasolabial folds. Serious complications after ArteFill injections, such as granuloma formation, have not been reported due to the reduction of PMMA microspheres smaller than 20 microm to less than 1% "by the number." Minor technique–related side effects, however, may occur during the initial learning curve. Patient and physician satisfaction with ArteFill has been shown to be greater than 90%.

Exclusive Author Commentary
Gottfried Lemperle, 10/14/09

The indications and suggested applications can be adopted for all other fillers, whether liquid (HA) or particulate (Sculptra, Radiesse, and ArteFill). Most dermal fillers in the US are approved for injections in nasolabial folds, only. However, physicians are independently able to use medical products "off-label" as they see fit for the benefit of their patients. If someone runs into troubles for technical or poduct related reasons, the section on managing "Complications" is highly recommended, since they can occur after all dermal fillers.

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