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Chronic allograft nephropathy – a clinical syndrome: early detection and the potential role of proliferation signal inhibitors
Clinical Transplantation, 09/11/09

Campistol JM et al. – Chronic allograft nephropathy leads to the majority of late graft loss following renal transplantation. Detection of CAN is often too late to permit early intervention and successful management. Most current strategies for managing CAN rely on minimizing or eliminating calcineurin inhibitors once CAN has become established. The proliferation signal inhibitors everolimus and sirolimus have potent immunosuppressive and antiproliferative actions, with the potential to alter the natural history of CAN by reducing CNI exposure whilst avoiding acute rejection.

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