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Wolf MT et al. – The authors describe a set of algorithms and a novel miniature device that together can autonomously position electrodes in neural tissue to obtain high–quality extracellular recordings. This robotic system moves each electrode to detect the signals of individual neurons, optimize the signal quality of a target neuron, and then maintain this signal over time. Such neuronal signals provide the key inputs for emerging neuroprosthetic medical devices and serve as the foundation of basic neuroscientific and medical research.

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