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See Latest ArticlesOutcome of surgical treatment in non-lesional intractable childhood epilepsy
Seizure - European Journal of Epilepsy, 08/25/09
Seo JH et al. – In children with intractable epilepsy and no abnormal lesions on MRI, epilepsy surgery should be strongly considered when cortical pathology can be identified from other studies.
Methods- Study of seizure outcomes after epilepsy surgery in non-lesional neocortical pediatric epilepsy
- Retrospective study of 27 pts with intractable childhood epilepsy who had epilepsy surgery between 1999-2006 and no detectable lesions on MRI
- Assessment of surgical outcome ≥ 2 yrs postoperatively
- Review of clinical characteristics, surgical outcome, pathologic findings, surgery type, localizing features on SPECT, FDG-PET, and long-term video-EEG
- Engel class I outcome postoperatively for 18 pts (67%)
- Mean follow-up duration: 4.3 yrs (range, 2.2–9 yrs)
- Focal localizing features on ictal SPECT for 18 of 27 cases (67%)
- abnormal findings on PET for 21 of 27 cases (78%)
- Most common procedure: single lobectomy in 20 pts (74%)
- Multilobar resection in 7 pts (26%)
- Most common finding during pathological examination: cortical dysplasia in 15 (56%) cases
- Gliosis in 2 pts (7%)
- Non-specific pathologic findings in 10 pts (37%)/li>
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