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Breast cancer susceptibility variants alter risks in familial disease
Journal of Medical Genetics, 08/19/09

Latif A et al. – The study confirms that susceptibility variants in FGFR2, TOX3, MAP3K1, and on chromosome 8q are all associated with increased risk of cancer in individuals with a family history of breast cancer, whereas CASP8 is protective in this context. The level of risk is dependent upon the strength of the family history and the presence of a BRCA1/2 mutation and contributes to the understanding of the use of these variants in clinical risk prediction.

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