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Role of NK and NKT cells in solid organ transplantation
Transplant International, 08/18/09
Pratschke J et al. – NK cells are influenced by immunosuppressive therapies such as calcineurin inhibitors or steroids. As NK and natural killer T cells have also been shown to play a profound role in allograft tolerance induction, this review summarizes the major findings to highlight the functional role of these lymphocyte subsets, which may constitute an underestimated mechanism affecting graft outcome in solid organ transplantation.
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