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Combined modality treatment of newly diagnosed glioblastoma multiforme in a regional neurosurgical centre
Journal of Clinical Neuroscience, 07/28/09

Gauden AJ et al. - Study demonstrates that patients with glioblastoma multiforme (GBM) undergoing maximal resection of the tumour followed by adjuvant radiotherapy and chemotherapy have an improved survival compared to patients undergoing either subtotal resection or biopsy alone; this survival benefit was achieved in a regional neurosurgical centre with minimal additional toxicity.

• Study examines the “local experience” of the Stupp protocol in the treatment of pts with newly diagnosed GBM
• Particular emphasis was given to the extent of surgical resection and its effect on survival
• 31 pts who underwent combined modality treatment according to the Stupp protocol were assessed retrospectively
• Variables assessed were:
  • Extent of surgery
  • Size and site of the tumour
  • Age and performance status
• Primary end points: overall survival (OS) and progression-free survival (PFS)

• Median OS was:
  • 33 mo for macroscopic tumour resection (9 pts; 29%)
  • 15 mo for debulking (15; 48%), and
  • 9 mo for biopsy (7; 22%)
• Macroscopic tumour resection resulted in improved OS and PFS vs 2 less radical surgical options

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