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Acinic Cell Carcinoma With High-grade Transformation: A Report of 9 Cases With Immunohistochemical Study and Analysis of TP53 and HER-2/neu Genes
American Journal of Surgical Pathology , 08/06/09
Skalova A et al. – High–grade transformation of acinic cell carcinoma is a rare phenomenon characterized by histologic progression of low–grade AciCC to high–grade adenocarcinoma or undifferentiated carcinoma. The high propensity for LN metastases indicates the need for neck dissection at the time of diagnosis.
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