Surgery Medical News about Bacille Calmette-Guerin, Statin, Bladder cancer

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Intravesical bacille Calmette-Guerin therapy for non-muscle-invasive bladder cancer: Effects of concurrent statin therapy
Journal of the American College of Surgeons, 07/10/09

Skolarus TA et al. - Concurrent statin use was not associated with adverse outcomes for patients undergoing BCG treatment for bladder cancer. While statins have a plausible biologic mechanism to reduce BCG efficacy, no differences were seen in this small pilot study.

Methods

An investigation of whether concurrent use of statin drugs are associated with worsened clinical outcomes in pts undergoing BCG treatment for non-muscle-invasive bladder cancer
Medical records of 120 pts undergoing BCG treatment during 1997-2007 were analyzed
Outcomes relative to statin use: tumor-progression events, total recurrences, disease-specific and overall mortality

Results

Among the 90 evaluable pts, no differences between groups with regard to tumor grade and stage distribution or smoking status
Statins were used during BCG therapy by 47.8% of pts
Comparison of no use vs use of statins:
- 8.5% vs 11.6% had local tumor progression
- 10.6% vs 9.3% underwent cystectomy, chemotherapy, or radiation therapy
- Metastatic disease developed in 6.7% vs 11.6%
Of the 27 pts who died of any cause, 12.5% vs 27.3% in the nonstatin vs statin groups, respectively, died of disease

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