Your Article Summary
See Latest ArticlesSurvival and recurrence after neo-adjuvant chemotherapy and liver resection for colorectal metastases – A 10-year study
European Journal of Surgical Oncology, 06/26/09
Karanjia ND et al. - In a study to assess the outcome of colorectal liver metastases (CRLM) treated by a combination of neo-adjuvant chemotherapy and surgery, it was determined that neo-adjuvant chemotherapy followed by liver surgery is associated with improved survival and low CIRM and re-resection rates.
Methods- 283 consecutive pts underwent liver resection for CRLM over 10 yrs with curative intent.
- Pts received chemotherapy preoperatively for synchronous and early (<2 yrs) metachronous metastases.
- Univariate and multivariate analyses were used to identify mortality risk factors.
- Overall survival (OS) at 1, 3, and 5 yrs was 90%, 59.2% and 46.1%, respectively.
- Disease free survival at 1, 3, and 5 yrs was 68.1%, 34.8%, and 27.9%, respectively.
- Operative mortality was 2.1% and morbidity was 23.7%.
- Pts with macroscopic diaphragm invasion by tumour, CEA >100 ng/ml, tumour size >5 cm or cancer involved resection margins (CIRM) had a significantly worse OS.
- Incidence of CIRM and re-resection was 4.9% and 4.5%, respectively.
Related Articles
Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk
Cancer Causes and Control, 10/02/09
Relevance Score: 96%
Colorectal cancer incidence and postmenopausal hormone use by type, recency, and duration in cancer prevention study II
Cancer Epidemiology, Biomarkers & Prevention, 10/28/09
Relevance Score: 93%
P73 expression and its clinical significance in colorectal cancer
Colorectal Disease, 10/19/09
Relevance Score: 93%
The effect of aspirin in the recurrence of colorectal adenomas: a meta-analysis of randomized controlled trials
Colorectal Disease, 10/15/09
Relevance Score: 91%
Aspirin as Colorectal Cancer Adjuvant Therapy
Gastroenterology, 10/05/09
Relevance Score: 91%
Today in Colo-Rectal...keeping you current
Receive free subspecialty "5-minute updates" via email
Neuronal immaturity in normoganglionic colon from cases of Hirschsprung disease, anorectal malformation, and idiopathic constipation
Journal of Pediatric Surgery, 12/19/09
Comparison of clinical outcomes and anorectal manometry in patients with congenital anorectal malformations treated with posterior sagittal anorectoplasty and laparoscopically assisted anorectal pull through
Journal of Pediatric Surgery, 12/18/09
The effects of biofeedback training of pelvic floor muscles on fecal incontinence
Journal of Pediatric Surgery, 12/18/09
Today in Hepatobiliary/Pancreas...keeping you current
Receive free subspecialty "5-minute updates" via email
Fundamental and intensive care of acute pancreatitis
Journal of Hepato-Biliary-Pancreatic Surgery, 12/20/09
Outcome of repeat hepatectomy in patients with hepatocellular carcinoma aged 75 years and older
Surgery, 12/19/09
Today in Surgical Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Prognostic Significance of Host- and Tumor-Related Factors in Patients with Gastric Cancer
World Journal of Surgery, 12/20/09
Comparative genomic hybridization for the diagnosis of melanoma
European Journal of Plastic Surgery, 12/20/09
Expression of thymidylate synthase determines the response of gastric cancer patients undergoing gastrectomy to 5-fluorouracil-based adjuvant chemotherapy
Langenbeck's Archives of Surgery, 12/20/09