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Knauer M et al. - In a study to investigate if extended chemotherapy (ExC) improved disease-free (DFS) and overall survival (OS) in early-stage breast cancer, it seems that ExC could not show advantages in terms of DFS and OS. Because multivariate analyses of retrospective data cannot account for all potential biases, these data require confirmation in randomized clinical trials. Until then, extended chemotherapy should be considered carefully. As in previous studies, no differences were found between neoadjuvant chemotherapy (NAC) and adjuvant therapy (AdC) groups.

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