Surgery Medical News about breast cancer

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials

3. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer

4. 2008 Exclusive Survey—Earnings: Good news for primary care income

5. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Adjuvant extension of chemotherapy after neoadjuvant therapy may not improve outcome in early-stage breast cancer
European Journal of Surgical Oncology, 06/26/09

Knauer M et al. - In a study to investigate if extended chemotherapy (ExC) improved disease-free (DFS) and overall survival (OS) in early-stage breast cancer, it seems that ExC could not show advantages in terms of DFS and OS. Because multivariate analyses of retrospective data cannot account for all potential biases, these data require confirmation in randomized clinical trials. Until then, extended chemotherapy should be considered carefully. As in previous studies, no differences were found between neoadjuvant chemotherapy (NAC) and adjuvant therapy (AdC) groups.

Methods

356 consecutive pts received NAC (45 pts), AdC (221 pts), or ExC (90 pts).
These 3 groups were analyzed to determine effects of ExC and to identify pts who might benefit.
NAC consisted in 93% of 3–6 cycles of epirubicin + docetaxel, AdC comprised EC ± taxanes in 72%.
Median age in the NAC, AdC, and ExC-groups was 54, 56 and 52 yrs with follow-up of 30, 57, and 55 mos.

Results

After NAC, 35% achieved downstaging and 10% pathologic complete remission.
ExC seemed to result in reduction of 5-yr DFS: vs 85% and 82% after NAC and AdC, DFS was 61% after ExC.
OS was not significantly affected (79, 91, and 78% after NAC, AdC and ExC).
In multivariate analysis after correction for age, menopausal status, stage, grading, hormone receptors, HER2-status, radiotherapy, and surgery, ExC seemed to adversely affect DFS, loco-regional and distant recurrence-rates.

<< Previous
Short and long-term advantages of transhiatal and transthoracic...

Next >>
Minimally invasive radioguided parathyroidectomy performed for...

Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers
Journal of Clinical Oncology, 10/29/09 Relevance Score: 74%%

Advanced Breast Cancer and Breast Cancer Mortality in Randomized Controlled Trials on Mammography Screening
Journal of Clinical Oncology, 11/09/09 Relevance Score: 72%%

Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients
Breast Cancer Research and Treatment, 10/27/09 Relevance Score: 72%%

Underweight and breast cancer recurrence and death: A report from the Korean breast cancer society
Journal of Clinical Oncology, 10/08/09 Relevance Score: 72%%

Reduced prediagnostic 25-hydroxyvitamin D levels in women with breast cancer: a nested case-control study
Cancer Epidemiology, Biomarkers & Prevention, 10/01/09 Relevance Score: 72%%