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Autoimmune-Mediated Oxidative Stress and Endothelial Dysfunction: Implications of Accelerated Vascular Injury in Type I Diabetes
Journal of Surgical Research, 06/26/09

Zimmerman MA et al. - While the specific mechanisms of persistent vascular injury are not clear, an increasing body of evidence suggests a dysregulated autoimmune response may contribute to the development of vascular injury. That is, the same inflammatory response that is responsible for pancreatic (beta)-cell destruction may facilitate chronic vascular endothelial injury prior to the onset of hyperglycemia.

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