Surgery Medical News about colorectal cancer

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Prognostic significance of peritoneal tumour cells identified at surgery for colorectal cancer
British Journal of Surgery, 06/24/09

Katoh H et al. - In a trial to determine whether detection of intraperitoneal tumour cells (IPCs) could be used as a prognostic marker for selecting pts at high risk of recurrence, it appears that IPCs were associated with haematogenous recurrence rather than peritoneal or local recurrence in pts with stage III disease. The presence of IPCs is a significant prognostic factor in pts with stage III colorectal cancer (CRC).

Methods

The study included 226 pts with CRC who underwent elective resection.
Clinical variables, including the presence of IPCs, were analysed for their prognostic significance.

Results

33 pts (14.6%) were positive for IPCs.
Univariable analysis indicated that the presence of IPCs was a significant prognostic factor in pts with stage III CRC; 5-yr disease-specific survival rate was 14% in IPC-positive pts vs 79% in those without IPCs.
Multivariable analysis showed that IPC positivity was the most robust prognostic factor in stage III disease, whereas nodal category (N1 or N2) showed no significant association with prognosis.
IPCs were associated with haematogenous recurrence rather than peritoneal or local recurrence in pts with stage III disease.

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