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Boutros C et al. - Although randomized controlled trials comparing RFA and MCT for hepatic ablation are lacking, review (based on level 2 data) supports that MCT may be optimal when larger necrosis zones and/or ablation of multiple lesions are the objectives. The data support that the potential procedural advantage(s) noted for ablation of CRHM and HCC >3 cm, is not supported for HCC <3 cm; moreover MCT shares with all other ablation modalities a high rate of locoregional recurrence in HCC; likely due to the multicentricity of this disease process.

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