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Impaired glucose-induced glucagon suppression after partial pancreatectomy
Journal of Clinical Endocrinology and Metabolism, 06/12/09
Schrader H et al. - The glucose-induced suppression in glucagon levels is lost after a 50% partial pancreatectomy in humans. This suggest that impaired alpha-cell function in patients with type 2 diabetes may also be secondary to reduced beta-cell mass. Alterations in glucagon regulation should be considered as a potential side effect of partial pancreatectomies.
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