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See Latest ArticlesA prospective trial comparing 1% lymphazurin vs 1% methylene blue in sentinel lymph node mapping of gastrointestinal tumors
Annals of Surgical Oncology, 06/03/09
Soni M et al. - In a study to compares lymphazurin (L) with methylene blue (M) in the sentinel lymph node mapping (SLNM) of gastrointestinal (GI) tumors, it seems that success rate, nodal positivity, average SLNs per pt, and overall accuracy were similar between L and M. Absence of anaphylaxis and lower cost make M more desirable than L in SLNM of GI tumors.
Methods- 122 consecutive pts with GI tumors were enrolled.
- All pts (pts) underwent SLNM with either L or M by subserosal injection of 2–5 mL of dye.
- Efficacy and rates of adverse reactions were compared between the 2 dyes.
- Pts were prospectively monitored for adverse reactions including anaphylaxis, development of blue hives, and tissue necrosis.
- Of 122 pts, 60 (49.2%) underwent SLNM using L and 62 (50.8%) underwent SLNM using M.
- Colon cancer (CrCa) was the most common site in both groups.
- Success rate of L and M in SLNM was 96.6% and 96.7%, respectively, with similar total numbers of lymph nodes per pt, SLNs per pt (<3), nodal positivity, skip metastasis, and accuracy.
- The only adverse reaction in the L group was oxygen desaturation >5% in 5% (3/60) of pts, compared with none in the M group.
- Cost per vial of L was $210 vs $7 for M.
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