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See Latest ArticlesSuccessful Up-front Combination Therapy in a Patient With Idiopathic Pulmonary Hypertension and Patent Foramen Ovale: An Alternative to Epoprostenol Therapy
The Journal of Heart and Lung Transplantation, 05/29/09
Pitsiou GG et al. - The authors report the case of a 40-year-old woman with idiopathic pulmonary hypertension in New York Heart Association class III to IV, who was admitted in the intensive care unit with hemodynamic compromise and severe hypoxemia due to right-to-left shunt throughout a PFO. Combination therapy initially with inhaled iloprost and sildenafil, and then addition of an endothelin A receptor–selective antagonist, resulted in impressive improvement in oxygenation with reversal of the right-to-left shunt and marked improvement in functional class of the patient.
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