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Mucoepidermoid Carcinoma of the Cervix: Another Tumor With the t(11;19)-associated CRTC1-MAML2 Gene Fusion
American Journal of Surgical Pathology , 05/26/09
Lennerz JKM et al. - The results demonstrate that cervical tumors defined as MEC by strict morphologic criteria harbor genetic aberrations involving the genes characteristically rearranged in MEC of the salivary glands, and suggest that cervical MEC is an entity distinct from conventional cervical adenosquamous carcinoma. The development of drug therapy targeted to the genes rearranged in MEC underscores the importance of correct classification of cervical MEC because the diagnosis may hold therapeutic implications different from other cervical malignancies.
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