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The effect of topical analgesics on ex vivo skin growth and human keratinocyte and fibroblast behavior
Wound Repair and Regeneration, 05/26/09
Harris KL et al. - Ketorolac was the most cytotoxic. Bupivacaine showed cytotoxicity in a dose-dependent manner with only the very highest concentrations having a significant inhibitory effect. Lidocaine showed no evidence of cytotoxicity at the concentrations tested in either the in vitro cell studies or the ex vivo explant model. Topical analgesics alter keratinocyte and fibroblast behavior and such inhibition may affect wound healing.
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