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Improvement of atherosclerotic markers in non-diabetic patients after bariatric surgery
Obesity Surgery, 07/18/2012
Clinical Article
Saleh MH et al. – This study shows that severely obese, non–diabetic patients who had pronounced weight loss after bariatric surgery had an overall improvement in brachial flow–mediated dilation, CIMT, high–sensitivity CRP, and glucose and lipid metabolism. The best responses of the brachial flow–mediated dilation after surgery were observed in non–smokers and in younger subjects.
Methods- Forty–seven obese individuals with body mass index >40 kg/m2 underwent bariatric surgery and returned for post–procedure assessment between 6 and 19 months after surgery.
- Ninety–three percent of patients were female.
- Their age ranged from 18 to 65 (mean 41) years old at baseline.
- Baseline was defined as the maximum of 30 days before surgery.
- Before and after surgery, all patients were subjected to a brachial artery ultrasound examination to evaluate endothelial–dependent dilation, CIMT by ultrasound, and laboratory analyses including glucose, lipid and inflammatory profiles were performed.
- This study shows that severely obese, non–diabetic patients who had pronounced weight loss after bariatric surgery had an overall improvement in brachial flow–mediated dilation, CIMT, high–sensitivity CRP, and glucose and lipid metabolism.
- The best responses of the brachial flow–mediated dilation after surgery were observed in non–smokers and in younger subjects.
