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Surgery - Clinical Pharmacology News Articles

MDLinx Surgery is your ultimate resource for the latest General Surgery and subspecialty surgery news articles published in over 2,000 peer-reviewed medical journals and popular press. Our diligent team of medical editor’s rank sort and summarize Surgery news articles with topics ranging from: Cardiac Surgery, Critical Care, Vascular, Thoracic, Peds Surgery, Neurosurgery and much more. On this page you may also find bonus content that includes articles highlighted by our physician editor, D. Scott Cunningham, MD, PhD, that are “must-read “ as well as clinical pearls taken from our Smartest Doc quiz competition.

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Latest (2) Full Text Articles (57)
Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Risk of colectomy in patients with ulcerative colitis under thiopurine treatment Journal of Crohn's and Colitis, April 17, 2014    Clinical Article

2 Impact of preoperative immunosuppressive agents on postoperative outcomes in Crohn's disease Diseases of the Colon and Rectum, April 17, 2014    Clinical Article

Prior Articles

3 Using protamine can significantly reduce the incidence of bleeding complications after carotid endarterectomy without increasing the risk of ischemic cerebral events World Journal of Surgery, April 16, 2014    Clinical Article

4 Safety of epidural analgesia in the perioperative care of patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy Annals of Surgical Oncology, April 16, 2014    Clinical Article

5 The analgesic efficacy and safety of nefopam in patient-controlled analgesia after cardiac surgery: A randomized, double-blind, prospective study The Journal of International Medical Research, April 16, 2014    Clinical Article

6 Laparoscopic surgery for gastro-esophageal acid reflux disease Best Practice & Research Clinical Gastroenterology , April 14, 2014    Review Article

7 Quality of life after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy: A prospective study of 216 patients European Journal of Surgical Oncology, April 11, 2014    Clinical Article

8 Thromboelastogram-guided enoxaparin dosing does not confer protection from deep venous thrombosis: A randomized controlled pilot trial The Journal of Trauma and Acute Care Surgery, April 9, 2014    Clinical Article

9 The diagnostic yield of upper endoscopy procedures in children- Is it cost effective? Current Gastroenterology Reports, April 7, 2014    Clinical Article

10 Morbidity and mortality of cytoreduction with intraperitoneal chemotherapy: Outcomes from the ACS NSQIP database Annals of Surgical Oncology, April 7, 2014    Clinical Article

11 Treatment of suspected acute perforated appendicitis with antibiotics and interval appendectomy Journal of Pediatric Surgery, April 3, 2014    Clinical Article

12 Neoadjuvant chemotherapy with S-1 and cisplatin followed by D2 gastrectomy with para-aortic lymph node dissection for gastric cancer with extensive lymph node metastasis British Journal of Surgery, April 1, 2014    Clinical Article

13 Duration of antibiotic treatment after appendicectomy for acute complicated appendicitis British Journal of Surgery, March 31, 2014    Clinical Article

14 A nomogram for predicting locoregional recurrence in primary breast cancer patients who received breast-conserving surgery after neoadjuvant chemotherapy Journal of Surgical Oncology, March 28, 2014    Clinical Article

15 Daptomycin and its immunomodulatory effect: Consequences for antibiotic treatment of methicillin-resistant staphylococcus aureus wound infections after heart surgery Frontiers in Immunology, March 28, 2014    Clinical Article

16 Midazolam with meperidine and dexmedetomidine vs. midazolam with meperidine for sedation during ERCP: prospective, randomized, double-blinded trial Endoscopy, March 27, 2014    Clinical Article

17 Patterns of recurrence following complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer Journal of Surgical Oncology, March 27, 2014    Clinical Article

18 Addition of mesalazine for subclinical post-surgical endoscopic recurrence of Crohn's disease despite preventive thiopurine therapy. A case-control study Journal of Gastroenterology and Hepatology, March 27, 2014    Clinical Article

19 Telaprevir drug monitoring during antiviral therapy of hepatitis C graft infection after liver transplantation Liver International, March 27, 2014    Clinical Article

20 Carvedilol vs. esophageal variceal band ligation in the primary prophylaxis of variceal hemorrhage: A multicentre randomized controlled trial Journal of Hepatology, March 26, 2014    Clinical Article

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Clinical Pearls in Surgery

Highlights in Surgery

Epidural anesthesia reduces post-CABG pain

As published in the Journal of Cardiac Surgery, thoracic epidural anesthesia (TEA) plus general anesthesia (GA) is superior to GA alone in managing post-operative CABG pain. Forty patients undergoing elective CABG were randomized to receive TEA (0.25% bipivacaine [10-20 mg/h]) intra-operatively and for 24 h post-operatively plus GA or GA alone. Post-operative pain at rest and with coughing was significantly less for up to 1 month post-operatively in the TEA + GA group compared to the GA alone group. Furthermore, analgesic use, mechanical ventilation time, ICU stay time, and hospital stay time were reduced in the TEA + GA group compared to the GA alone group.

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NT-proBNP predicts outcome following emergent surgery

As published in the British Journal of Anaesthesia, measurement of N-terminal pro B-type natruiretic peptide (NT-proBNP) pre- and post-operatively predicts outcome in patients > 50 years of age (n=297) undergoing emergent non-cardiac surgery. A pre-operative NT-proBNP > 725 pg/ml was associated with a 4.8-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. Similarly, a post-operative NT-proBNP > 1600 pg/ml was associated with a 4.0-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. A pre-operative NT-proBNP > 1740 pg/ml was associated with a 6.9 RR for major adverse cardiac events during the post-operative hospital stay.

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Increased risk of skin cancer in RCC treated with multikinase inhibitors

As published in Dermatologic Surgery, RCC patients (n=69) treated with multikinase inhibitors are at increased risk for squamous cell carcinomas and basal cell carcinomas. After a median treatment of 13.5 months, 13.5% and 6.3% of patients treated with sorafenib and sunitinib developed skin cancer, respectively.

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