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Surgery - Clinical Pharmacology News Articles

MDLinx Surgery is your ultimate resource for the latest General Surgery and subspecialty surgery news articles published in over 2,000 peer-reviewed medical journals and popular press. Our diligent team of medical editor’s rank sort and summarize Surgery news articles with topics ranging from: Cardiac Surgery, Critical Care, Vascular, Thoracic, Peds Surgery, Neurosurgery and much more. On this page you may also find bonus content that includes articles highlighted by our physician editor, D. Scott Cunningham, MD, PhD, that are “must-read “ as well as clinical pearls taken from our Smartest Doc quiz competition.

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Articles

Latest (1) Full Text Articles (57)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

1 Directly acting antivirals (DAAS) for the treatment of chronic hepatitis C virus infection in liver transplant patients: A flood of opportunity American Journal of Transplantation, April 23, 2014    Review Article

Prior Articles

2 Role of surgery in the treatment of patients with high-risk neuroblastoma who have a poor response to induction chemotherapy Journal of Pediatric Surgery, April 22, 2014    Clinical Article

3 The relation between patients NRS pain scores and their desire for additional opioids after surgery Pain Practice, April 22, 2014    Clinical Article

4 Use of ranolazine in the prevention and treatment of postoperative atrial fibrillation in patients undergoing cardiac surgery Annals of Pharmacotherapy, April 18, 2014    Review Article

5 Risk of colectomy in patients with ulcerative colitis under thiopurine treatment Journal of Crohn's and Colitis, April 17, 2014    Clinical Article

6 Impact of preoperative immunosuppressive agents on postoperative outcomes in Crohn's disease Diseases of the Colon and Rectum, April 17, 2014    Clinical Article

7 Using protamine can significantly reduce the incidence of bleeding complications after carotid endarterectomy without increasing the risk of ischemic cerebral events World Journal of Surgery, April 16, 2014    Clinical Article

8 Safety of epidural analgesia in the perioperative care of patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy Annals of Surgical Oncology, April 16, 2014    Clinical Article

9 The analgesic efficacy and safety of nefopam in patient-controlled analgesia after cardiac surgery: A randomized, double-blind, prospective study The Journal of International Medical Research, April 16, 2014    Clinical Article

10 Laparoscopic surgery for gastro-esophageal acid reflux disease Best Practice & Research Clinical Gastroenterology , April 14, 2014    Review Article

11 Quality of life after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy: A prospective study of 216 patients European Journal of Surgical Oncology, April 11, 2014    Clinical Article

12 Thromboelastogram-guided enoxaparin dosing does not confer protection from deep venous thrombosis: A randomized controlled pilot trial The Journal of Trauma and Acute Care Surgery, April 9, 2014    Clinical Article

13 The diagnostic yield of upper endoscopy procedures in children- Is it cost effective? Current Gastroenterology Reports, April 7, 2014    Clinical Article

14 Morbidity and mortality of cytoreduction with intraperitoneal chemotherapy: Outcomes from the ACS NSQIP database Annals of Surgical Oncology, April 7, 2014    Clinical Article

15 Treatment of suspected acute perforated appendicitis with antibiotics and interval appendectomy Journal of Pediatric Surgery, April 3, 2014    Clinical Article

16 Neoadjuvant chemotherapy with S-1 and cisplatin followed by D2 gastrectomy with para-aortic lymph node dissection for gastric cancer with extensive lymph node metastasis British Journal of Surgery, April 1, 2014    Clinical Article

17 Duration of antibiotic treatment after appendicectomy for acute complicated appendicitis British Journal of Surgery, March 31, 2014    Clinical Article

18 A nomogram for predicting locoregional recurrence in primary breast cancer patients who received breast-conserving surgery after neoadjuvant chemotherapy Journal of Surgical Oncology, March 28, 2014    Clinical Article

19 Daptomycin and its immunomodulatory effect: Consequences for antibiotic treatment of methicillin-resistant staphylococcus aureus wound infections after heart surgery Frontiers in Immunology, March 28, 2014    Clinical Article

20 Midazolam with meperidine and dexmedetomidine vs. midazolam with meperidine for sedation during ERCP: prospective, randomized, double-blinded trial Endoscopy, March 27, 2014    Clinical Article

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Clinical Pearls in Surgery

Highlights in Surgery

Epidural anesthesia reduces post-CABG pain

As published in the Journal of Cardiac Surgery, thoracic epidural anesthesia (TEA) plus general anesthesia (GA) is superior to GA alone in managing post-operative CABG pain. Forty patients undergoing elective CABG were randomized to receive TEA (0.25% bipivacaine [10-20 mg/h]) intra-operatively and for 24 h post-operatively plus GA or GA alone. Post-operative pain at rest and with coughing was significantly less for up to 1 month post-operatively in the TEA + GA group compared to the GA alone group. Furthermore, analgesic use, mechanical ventilation time, ICU stay time, and hospital stay time were reduced in the TEA + GA group compared to the GA alone group.

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NT-proBNP predicts outcome following emergent surgery

As published in the British Journal of Anaesthesia, measurement of N-terminal pro B-type natruiretic peptide (NT-proBNP) pre- and post-operatively predicts outcome in patients > 50 years of age (n=297) undergoing emergent non-cardiac surgery. A pre-operative NT-proBNP > 725 pg/ml was associated with a 4.8-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. Similarly, a post-operative NT-proBNP > 1600 pg/ml was associated with a 4.0-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. A pre-operative NT-proBNP > 1740 pg/ml was associated with a 6.9 RR for major adverse cardiac events during the post-operative hospital stay.

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Increased risk of skin cancer in RCC treated with multikinase inhibitors

As published in Dermatologic Surgery, RCC patients (n=69) treated with multikinase inhibitors are at increased risk for squamous cell carcinomas and basal cell carcinomas. After a median treatment of 13.5 months, 13.5% and 6.3% of patients treated with sorafenib and sunitinib developed skin cancer, respectively.

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