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Surgery - Clinical Pharmacology News & Articles

MDLinx Surgery is your ultimate resource for the latest General Surgery and subspecialty surgery news articles published in over 2,000 peer-reviewed medical journals and popular press. Our diligent team of medical editor’s rank sort and summarize Surgery news articles with topics ranging from: Cardiac Surgery, Critical Care, Vascular, Thoracic, Peds Surgery, Neurosurgery and much more. On this page you may also find bonus content that includes articles highlighted by our physician editor, D. Scott Cunningham, MD, PhD, that are “must-read “ as well as clinical pearls taken from our Smartest Doc quiz competition.

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Articles

Latest (1) Full Text Articles (57)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

101 Effect of a Preoperative Gabapentin on Postoperative Analgesia in Patients with Inflammatory Bowel Disease Following Major Bowel Surgery: A Randomized, Placebo-Controlled Trial Pain Practice, April 11, 2013    Clinical Article

102 Epidural vs. intravenous fentanyl during colorectal surgery using a double-blind, double-dummy design Acta Anaesthesiologica Scandinavica, April 11, 2013    Clinical Article

103 A Review of Thrombosis and Antithrombotic Therapy in Microvascular Surgery European Surgical Research, April 11, 2013    Review Article

104 Risk factors for anastomotic leakage and favorable antimicrobial treatment as empirical therapy for intra-abdominal infection in patients undergoing colorectal surgery Surgery Today, April 10, 2013    Clinical Article

105 Effects of vildagliptin (Galvus®) therapy in patients with type 2 diabetes mellitus after heart transplantation Full Text Drug Design, Development and Therapy, April 10, 2013    Clinical Article

106 Prevention of De Novo Hepatitis B in Recipients of Core Antibody-Positive Livers With Lamivudine and Other Nucleos(t)ides: A 12-Year Experience Transplantation, April 10, 2013    Clinical Article

107 Interpreting Tacrolimus Concentrations During Pregnancy and Postpartum Transplantation, April 10, 2013    Review Article

108 Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections on Subcutaneous Fat: A Randomized, Controlled Trial Aesthetic Surgery Journal, April 9, 2013    Clinical Article

109 Beta-blockers for the treatment of problematic hemangiomas, Canadian Journal of Plastic Surgery, April 9, 2013    Clinical Article

110 Lack of Effectiveness of Sodium Bicarbonate in Preventing Kidney Injury in Patients Undergoing Cardiac Surgery: A Randomized Controlled Trial Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, April 9, 2013    Clinical Article

111 Differential Effect of Everolimus on Progression of Early and Late Cardiac Allograft Vasculopathy in Current Clinical Practice American Journal of Transplantation, April 8, 2013    Clinical Article

112 Internal Mammary Artery Harvesting Influences Antibiotic Penetration Into Presternal Tissue Annals of Thoracic Surgery, April 8, 2013    Clinical Article

113 Colistin effectiveness and nephrotoxicity: experience from a tertiary care burns unit in Oman European Journal of Plastic Surgery, April 8, 2013    Clinical Article

114 Impact of a Protocol Advocating Dexmedetomidine Over Propofol Sedation After Robotic-Assisted Direct Coronary Artery Bypass Surgery on Duration of Mechanical Ventilation and Patient Safety Annals of Pharmacotherapy, April 5, 2013    Clinical Article

115 Interpreting Tacrolimus Concentrations During Pregnancy and Postpartum Transplantation, April 5, 2013    Review Article

116 Is intraoperative dexmedetomidine a new option for postoperative pain treatment? A meta-analysis of randomized controlled trials Pain, April 4, 2013    Evidence Based Medicine    Review Article    Clinical Article

117 The efficacy of caudal dexmedetomidine on stress response and postoperative pain in pediatric cardiac surgery Full Text Annals of Cardiac Anaesthesia, April 2, 2013    Clinical Article

118 Impact of Adding Aspirin to Beta-Blocker and Statin in High-Risk Patients Undergoing Major Vascular Surgery Annals of Vascular Surgery, April 2, 2013    Clinical Article

119 Adefovir treatment for chronic hepatitis B in heart transplant recipients Clinical Transplantation, April 2, 2013    Clinical Article

120 Thromboprophylaxis for trauma patients Cochrane Reviews, April 1, 2013    Review Article

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Clinical Pearls in Surgery

Highlights in Surgery

Epidural anesthesia reduces post-CABG pain

As published in the Journal of Cardiac Surgery, thoracic epidural anesthesia (TEA) plus general anesthesia (GA) is superior to GA alone in managing post-operative CABG pain. Forty patients undergoing elective CABG were randomized to receive TEA (0.25% bipivacaine [10-20 mg/h]) intra-operatively and for 24 h post-operatively plus GA or GA alone. Post-operative pain at rest and with coughing was significantly less for up to 1 month post-operatively in the TEA + GA group compared to the GA alone group. Furthermore, analgesic use, mechanical ventilation time, ICU stay time, and hospital stay time were reduced in the TEA + GA group compared to the GA alone group.

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NT-proBNP predicts outcome following emergent surgery

As published in the British Journal of Anaesthesia, measurement of N-terminal pro B-type natruiretic peptide (NT-proBNP) pre- and post-operatively predicts outcome in patients > 50 years of age (n=297) undergoing emergent non-cardiac surgery. A pre-operative NT-proBNP > 725 pg/ml was associated with a 4.8-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. Similarly, a post-operative NT-proBNP > 1600 pg/ml was associated with a 4.0-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. A pre-operative NT-proBNP > 1740 pg/ml was associated with a 6.9 RR for major adverse cardiac events during the post-operative hospital stay.

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Increased risk of skin cancer in RCC treated with multikinase inhibitors

As published in Dermatologic Surgery, RCC patients (n=69) treated with multikinase inhibitors are at increased risk for squamous cell carcinomas and basal cell carcinomas. After a median treatment of 13.5 months, 13.5% and 6.3% of patients treated with sorafenib and sunitinib developed skin cancer, respectively.

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