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Surgery - Clinical Pharmacology News & Articles

MDLinx Surgery is your ultimate resource for the latest General Surgery and subspecialty surgery news articles published in over 2,000 peer-reviewed medical journals and popular press. Our diligent team of medical editor’s rank sort and summarize Surgery news articles with topics ranging from: Cardiac Surgery, Critical Care, Vascular, Thoracic, Peds Surgery, Neurosurgery and much more. On this page you may also find bonus content that includes articles highlighted by our physician editor, D. Scott Cunningham, MD, PhD, that are “must-read “ as well as clinical pearls taken from our Smartest Doc quiz competition.

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Articles

Latest (2) Full Text Articles (57)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

801 Evaluating the Safety and Efficacy of BMI-Based Preoperative Administration of Low-Molecular-Weight Heparin in Morbidly Obese Patients Undergoing Roux-en-Y Gastric Bypass Surgery Obesity Surgery, April 22, 2011

802 Analgesic Effectiveness of Dipyrone (Metamizol) for Postoperative Pain after Herniorrhaphy: A Randomized, Double-Blind, Dose-Response Study Pain Practice, April 22, 2011

803 Minimally Invasive Esophagectomy is Safe and Effective Following Neoadjuvant Chemoradiation Therapy Annals of Surgical Oncology, April 21, 2011

804 Early clopidogrel use in non-ST elevation acute coronary syndrome and subsequent coronary artery bypass grafting American Heart Journal, April 21, 2011    Clinical Article

805 Improvement of gastrointestinal symptoms after conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in liver transplant patients Clinical Transplantation, April 21, 2011

806 The efficacy of preventive parasternal single injection of bupivacaine on intubation time, blood gas parameters, narcotic requirement, and pain relief after open heart surgery: A randomization clinical trial study Journal of Research in Medical Sciences, April 19, 2011    Clinical Article

807 Tramadol/paracetamol combination tablet for postoperative pain following ambulatory hand surgery: a double-blind, double-dummy, randomized, parallel-group trial Full Text Journal of Pain Research, April 19, 2011    Clinical Article

808 Botulinum Toxin Type A Inhibits Connective Tissue Growth Factor Expression in Fibroblasts Derived From Hypertrophic Scar Aesthetic Plastic Surgery, April 19, 2011

809 Multimodality therapeutic outcomes In anaplastic thyroid carcinoma: Improved survival in subgroups of patients with localized primary tumors Head & Neck, April 19, 2011

810 Routine use of Staging Thoracoscopy for Pancoast Tumors Without Overt Radiographic Chest Wall Invasion Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, April 19, 2011

811 Medium-Sized (3.1–5.0 cm) Hepatocellular Carcinoma: Transarterial Chemoembolization Plus Radiofrequency Ablation Versus Radiofrequency Ablation Alone Annals of Surgical Oncology, April 18, 2011

812 Treatment of Long-Lasting Persistent Atrial Fibrillation Using Minimally Invasive Surgery Combined With Irbesartan Full Text Annals of Thoracic Surgery, April 18, 2011

813 Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Improves Survival of Patients with Peritoneal Carcinomatosis from Gastric Cancer: Final Results of a Phase III Randomized Clinical Trial Annals of Surgical Oncology, April 15, 2011

814 Complete regression of locally advanced hepatocellular carcinoma induced by sorafenib allowing curative resection Liver International, April 14, 2011

815 Comparison of three concentrations of simplex lidocaine in local anesthesia for inguinal hernia mesh-repairs Hernia, April 13, 2011

816 Improved Outcomes Associated With Intraoperative Steroid Use in High-Risk Pediatric Cardiac Surgery Full Text Annals of Thoracic Surgery, April 13, 2011

817 Selective neck dissection as an early salvage intervention for clinically persistent nodal disease following chemoradiation Head & Neck, April 13, 2011

818 The impact of renal replacement therapy before or after living donor liver transplantation Clinical Transplantation, April 12, 2011

819 Effect of early risedronate treatment on bone mineral density and bone turnover markers after liver transplantation: a prospective single-center study Transplant International, April 11, 2011

820 Randomized phase II clinical trial of avotermin versus placebo for scar improvement British Journal of Surgery, April 8, 2011

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Clinical Pearls in Surgery

Highlights in Surgery

Epidural anesthesia reduces post-CABG pain

As published in the Journal of Cardiac Surgery, thoracic epidural anesthesia (TEA) plus general anesthesia (GA) is superior to GA alone in managing post-operative CABG pain. Forty patients undergoing elective CABG were randomized to receive TEA (0.25% bipivacaine [10-20 mg/h]) intra-operatively and for 24 h post-operatively plus GA or GA alone. Post-operative pain at rest and with coughing was significantly less for up to 1 month post-operatively in the TEA + GA group compared to the GA alone group. Furthermore, analgesic use, mechanical ventilation time, ICU stay time, and hospital stay time were reduced in the TEA + GA group compared to the GA alone group.

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NT-proBNP predicts outcome following emergent surgery

As published in the British Journal of Anaesthesia, measurement of N-terminal pro B-type natruiretic peptide (NT-proBNP) pre- and post-operatively predicts outcome in patients > 50 years of age (n=297) undergoing emergent non-cardiac surgery. A pre-operative NT-proBNP > 725 pg/ml was associated with a 4.8-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. Similarly, a post-operative NT-proBNP > 1600 pg/ml was associated with a 4.0-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. A pre-operative NT-proBNP > 1740 pg/ml was associated with a 6.9 RR for major adverse cardiac events during the post-operative hospital stay.

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Increased risk of skin cancer in RCC treated with multikinase inhibitors

As published in Dermatologic Surgery, RCC patients (n=69) treated with multikinase inhibitors are at increased risk for squamous cell carcinomas and basal cell carcinomas. After a median treatment of 13.5 months, 13.5% and 6.3% of patients treated with sorafenib and sunitinib developed skin cancer, respectively.

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Most Popular Surgery Articles

Last month's top read Top Articles of 2012

1 Use of Selective Serotonin Reuptake Inhibitors Antidepressants and Bleeding Risk in Breast Cosmetic Surgery Aesthetic Plastic Surgery, April 22, 2013

2 Propranolol therapy of infantile hemangiomas: efficacy, adverse effects, and recurrence Pediatric Surgery International, March 28, 2013

3 Lateral internal sphincterotomy versus 0.25 % isosorbide dinitrate ointment for chronic anal fissures: a prospective randomized controlled trial Surgery Today, April 29, 2013

4 Risk factors for anastomotic leakage and favorable antimicrobial treatment as empirical therapy for intra-abdominal infection in patients undergoing colorectal surgery Surgery Today, April 10, 2013

5 Is intraoperative dexmedetomidine a new option for postoperative pain treatment? A meta-analysis of randomized controlled trials Pain, April 4, 2013    Evidence Based Medicine    Review Article

6 Preoperative statin therapy in cardiac surgery: a meta-analysis of 90 000 patients European Journal of Cardio-Thoracic Surgery, April 18, 2013    Evidence Based Medicine    Review Article

7 Timing of Surgical Antibiotic Prophylaxis and the Risk of Surgical Site Infection Antibiotic Prophylaxis Timing and SSI Risk JAMA Surgery, March 25, 2013    Review Article

8 Pressure Ulcer Development and Vasopressor Agents in Adult Critical Care Patients: A Literature Review Ostomy Wound Management, April 16, 2013    Free full text    Review Article

9 Should all acutely ill medical patients be treated with antithrombotic drugs? Thrombosis and Haemostasis, April 23, 2013    Free full text    Review Article

10 Effect of gentamicin lavage of the axillary surgical bed after lymph node dissection on drainage discharge volume The Breast, April 23, 2013

11 Prophylactic Perioperative Sodium Bicarbonate to Prevent Acute Kidney Injury Following Open Heart Surgery: A Multicenter Double-Blinded Randomized Controlled Trial PLoS Medicine, April 23, 2013    Free full text

12 Meta-analysis: peri-operative anti-TNF treatment and post-operative complications in patients with inflammatory bowel disease Alimentary Pharmacology and Therapeutics, April 18, 2013

13 Beta-blockers for the treatment of problematic hemangiomas, Canadian Journal of Plastic Surgery, April 9, 2013

14 Thromboprophylaxis for trauma patients Cochrane Reviews, April 1, 2013    Review Article

15 Postoperative pain trajectories in chronic pain patients undergoing surgery: the effects of chronic opioid pharmacotherapy on acute pain The Journal of Pain, October 31, 2011

16 Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections on Subcutaneous Fat: A Randomized, Controlled Trial Aesthetic Surgery Journal, April 9, 2013

17 Postoperative respiratory depression with pregabalin: A case series and a preoperative decision algorithm Pain Research and Management, October 27, 2011

18 Effect of a Preoperative Gabapentin on Postoperative Analgesia in Patients with Inflammatory Bowel Disease Following Major Bowel Surgery: A Randomized, Placebo-Controlled Trial Pain Practice, April 11, 2013

19 Pharmacotherapy Prevention and Management of Nutritional Deficiencies Post Roux-en-Y Gastric Bypass Obesity Surgery, April 15, 2013    Review Article

20 Efficacy of Cholestyramine Ointment in Reduction of Postoperative Pain and Pain during Defecation after Open Hemorrhoidectomy: Results of a Prospective, Single-center, Randomized, Double-blind, Placebo-controlled Trial World Journal of Surgery, February 27, 2013

Indexed Journals in Surgery: Surgery, Journal of the American College of Surgeons, Annals of Surgerymore

Other Topics in Surgery

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