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Surgery - Clinical Pharmacology News & Articles

MDLinx Surgery is your ultimate resource for the latest General Surgery and subspecialty surgery news articles published in over 2,000 peer-reviewed medical journals and popular press. Our diligent team of medical editor’s rank sort and summarize Surgery news articles with topics ranging from: Cardiac Surgery, Critical Care, Vascular, Thoracic, Peds Surgery, Neurosurgery and much more. On this page you may also find bonus content that includes articles highlighted by our physician editor, D. Scott Cunningham, MD, PhD, that are “must-read “ as well as clinical pearls taken from our Smartest Doc quiz competition.

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Articles

Latest (2) Full Text Articles (57)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

41 Prophylactic Perioperative Sodium Bicarbonate to Prevent Acute Kidney Injury Following Open Heart Surgery: A Multicenter Double-Blinded Randomized Controlled Trial Full Text PLoS Medicine, April 23, 2013    Clinical Article

42 Sofosbuvir and Daclatasvir Combination Therapy in a Liver Transplant Recipient With Severe Recurrent Cholestatic Hepatitis C American Journal of Transplantation, April 23, 2013

43 Should all acutely ill medical patients be treated with antithrombotic drugs? Full Text Thrombosis and Haemostasis, April 23, 2013    Review Article

44 Use of Selective Serotonin Reuptake Inhibitors Antidepressants and Bleeding Risk in Breast Cosmetic Surgery Aesthetic Plastic Surgery, April 22, 2013    Clinical Article

45 The Role of Hydroxyethyl Starch in Preventing Surgical-Site Infections and Nipple Necrosis in Patients Undergoing Reduction Mammaplasty: A Prospective Case-Control Study of 334 Patients Aesthetic Plastic Surgery, April 22, 2013    Review Article

46 Antithrombotic Treatment in Transcatheter Aortic Valve Implantation: Insights for Cerebrovascular and Bleeding Events JACC - Journal of the American College of Cardiology, April 22, 2013    Clinical Article

47 Cold agglutinins in patients undergoing cardiac surgery requiring cardiopulmonary bypass The Journal of Thoracic and Cardiovascular Surgery, April 22, 2013    Review Article

48 Population pharmacokinetic analysis of tacrolimus in the first year after pediatric liver transplantation European Journal of Clinical Pharmacology, April 22, 2013    Clinical Article

49 Adjuvant Hepatic Arterial Infusion Chemotherapy after Hepatic Resection of Hepatocellular Carcinoma With Macroscopic Vascular Invasion World Journal of Surgery, April 19, 2013    Clinical Article

50 Effect of rikkunshito, a Japanese herbal medicine, on gastrointestinal symptoms and ghrelin levels in gastric cancer patients after gastrectomy Gastric Cancer, April 19, 2013    Clinical Article

51 Meta-analysis: peri-operative anti-TNF treatment and post-operative complications in patients with inflammatory bowel disease Alimentary Pharmacology and Therapeutics, April 18, 2013    Clinical Article

52 Preoperative statin therapy in cardiac surgery: a meta-analysis of 90 000 patients European Journal of Cardio-Thoracic Surgery, April 18, 2013    Evidence Based Medicine    Review Article    Clinical Article

53 Use of High-Dose Ganciclovir for the Treatment of Cytomegalovirus Replication in Solid Organ Transplant Patients With Ganciclovir Resistance-Inducing Mutations Transplantation, April 18, 2013    Clinical Article

54 Effect of chronic oral anticoagulation with warfarin on the durability and outcomes of endovascular aortic aneurysm repair Journal of Vascular Surgery, April 17, 2013    Review Article

55 Serum concentrations and pharmacokinetics of moxifloxacin in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass International Journal of Antimicrobial Agents, April 17, 2013    Clinical Article

56 Colorectal Cancer Surgery in Portal Hypertensive Patients: Does Adjuvant Oxaliplatin Affect Prognosis? Diseases of the Colon and Rectum, April 16, 2013    Clinical Article

57 Use of the neo-adjuvant exemestane in post-menopausal estrogen receptor-positive breast cancer: A randomized phase II trial (PTEX46) to investigate the optimal duration of preoperative endocrine therapy The Breast, April 16, 2013    Clinical Article

58 Pressure Ulcer Development and Vasopressor Agents in Adult Critical Care Patients: A Literature Review Full Text Ostomy Wound Management, April 16, 2013    Review Article

59 Pharmacotherapy Prevention and Management of Nutritional Deficiencies Post Roux-en-Y Gastric Bypass Obesity Surgery, April 15, 2013    Review Article

60 Comparison of Emergence Time in Children Undergoing Minor Surgery According to Anesthetic: Desflurane and Sevoflurane Full Text Yonsei Medical Journal, April 15, 2013    Clinical Article

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Clinical Pearls in Surgery

Highlights in Surgery

Epidural anesthesia reduces post-CABG pain

As published in the Journal of Cardiac Surgery, thoracic epidural anesthesia (TEA) plus general anesthesia (GA) is superior to GA alone in managing post-operative CABG pain. Forty patients undergoing elective CABG were randomized to receive TEA (0.25% bipivacaine [10-20 mg/h]) intra-operatively and for 24 h post-operatively plus GA or GA alone. Post-operative pain at rest and with coughing was significantly less for up to 1 month post-operatively in the TEA + GA group compared to the GA alone group. Furthermore, analgesic use, mechanical ventilation time, ICU stay time, and hospital stay time were reduced in the TEA + GA group compared to the GA alone group.

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NT-proBNP predicts outcome following emergent surgery

As published in the British Journal of Anaesthesia, measurement of N-terminal pro B-type natruiretic peptide (NT-proBNP) pre- and post-operatively predicts outcome in patients > 50 years of age (n=297) undergoing emergent non-cardiac surgery. A pre-operative NT-proBNP > 725 pg/ml was associated with a 4.8-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. Similarly, a post-operative NT-proBNP > 1600 pg/ml was associated with a 4.0-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. A pre-operative NT-proBNP > 1740 pg/ml was associated with a 6.9 RR for major adverse cardiac events during the post-operative hospital stay.

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Increased risk of skin cancer in RCC treated with multikinase inhibitors

As published in Dermatologic Surgery, RCC patients (n=69) treated with multikinase inhibitors are at increased risk for squamous cell carcinomas and basal cell carcinomas. After a median treatment of 13.5 months, 13.5% and 6.3% of patients treated with sorafenib and sunitinib developed skin cancer, respectively.

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Most Popular Surgery Articles

Last month's top read Top Articles of 2012

1 Use of Selective Serotonin Reuptake Inhibitors Antidepressants and Bleeding Risk in Breast Cosmetic Surgery Aesthetic Plastic Surgery, April 22, 2013

2 Propranolol therapy of infantile hemangiomas: efficacy, adverse effects, and recurrence Pediatric Surgery International, March 28, 2013

3 Lateral internal sphincterotomy versus 0.25 % isosorbide dinitrate ointment for chronic anal fissures: a prospective randomized controlled trial Surgery Today, April 29, 2013

4 Risk factors for anastomotic leakage and favorable antimicrobial treatment as empirical therapy for intra-abdominal infection in patients undergoing colorectal surgery Surgery Today, April 10, 2013

5 Is intraoperative dexmedetomidine a new option for postoperative pain treatment? A meta-analysis of randomized controlled trials Pain, April 4, 2013    Evidence Based Medicine    Review Article

6 Preoperative statin therapy in cardiac surgery: a meta-analysis of 90 000 patients European Journal of Cardio-Thoracic Surgery, April 18, 2013    Evidence Based Medicine    Review Article

7 Timing of Surgical Antibiotic Prophylaxis and the Risk of Surgical Site Infection Antibiotic Prophylaxis Timing and SSI Risk JAMA Surgery, March 25, 2013    Review Article

8 Pressure Ulcer Development and Vasopressor Agents in Adult Critical Care Patients: A Literature Review Ostomy Wound Management, April 16, 2013    Free full text    Review Article

9 Should all acutely ill medical patients be treated with antithrombotic drugs? Thrombosis and Haemostasis, April 23, 2013    Free full text    Review Article

10 Effect of gentamicin lavage of the axillary surgical bed after lymph node dissection on drainage discharge volume The Breast, April 23, 2013

11 Prophylactic Perioperative Sodium Bicarbonate to Prevent Acute Kidney Injury Following Open Heart Surgery: A Multicenter Double-Blinded Randomized Controlled Trial PLoS Medicine, April 23, 2013    Free full text

12 Meta-analysis: peri-operative anti-TNF treatment and post-operative complications in patients with inflammatory bowel disease Alimentary Pharmacology and Therapeutics, April 18, 2013

13 Beta-blockers for the treatment of problematic hemangiomas, Canadian Journal of Plastic Surgery, April 9, 2013

14 Thromboprophylaxis for trauma patients Cochrane Reviews, April 1, 2013    Review Article

15 Postoperative pain trajectories in chronic pain patients undergoing surgery: the effects of chronic opioid pharmacotherapy on acute pain The Journal of Pain, October 31, 2011

16 Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections on Subcutaneous Fat: A Randomized, Controlled Trial Aesthetic Surgery Journal, April 9, 2013

17 Postoperative respiratory depression with pregabalin: A case series and a preoperative decision algorithm Pain Research and Management, October 27, 2011

18 Effect of a Preoperative Gabapentin on Postoperative Analgesia in Patients with Inflammatory Bowel Disease Following Major Bowel Surgery: A Randomized, Placebo-Controlled Trial Pain Practice, April 11, 2013

19 Pharmacotherapy Prevention and Management of Nutritional Deficiencies Post Roux-en-Y Gastric Bypass Obesity Surgery, April 15, 2013    Review Article

20 Efficacy of Cholestyramine Ointment in Reduction of Postoperative Pain and Pain during Defecation after Open Hemorrhoidectomy: Results of a Prospective, Single-center, Randomized, Double-blind, Placebo-controlled Trial World Journal of Surgery, February 27, 2013

Indexed Journals in Surgery: Surgery, Journal of the American College of Surgeons, Annals of Surgerymore

Other Topics in Surgery

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