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Surgery - Basic Science/Genetics News & Articles

MDLinx Surgery is your ultimate resource for the latest General Surgery and subspecialty surgery news articles published in over 2,000 peer-reviewed medical journals and popular press. Our diligent team of medical editor’s rank sort and summarize Surgery news articles with topics ranging from: Cardiac Surgery, Critical Care, Vascular, Thoracic, Peds Surgery, Neurosurgery and much more. On this page you may also find bonus content that includes articles highlighted by our physician editor, D. Scott Cunningham, MD, PhD, that are “must-read “ as well as clinical pearls taken from our Smartest Doc quiz competition.

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Articles

Latest (2) Full Text Articles (20)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

1 A worldwide trend of increasing primary adenocarcinoma of the lung Surgery Today, June 19, 2013    Review Article

2 The differential tissue expression of inflammatory, oxidative stress, and apoptosis markers in human uncontrolled non-heart-beating donors Transplantation, June 19, 2013    Clinical Article

Prior Articles

3 Liver transplantation normalizes serum hepcidin level and cures iron metabolism alterations in HFE hemochromatosis Hepatology, June 17, 2013    Review Article

4 Papillary microcarcinoma of the thyroid: clinical characteristics and BRAFv600e mutational status of 977 cases Annals of Surgical Oncology, June 12, 2013    Review Article

5 Cardioprotective mechanism of diazoxide involves the inhibition of succinate dehydrogenase Annals of Thoracic Surgery, June 12, 2013    Clinical Article

6 Human natural killer cells exhibit negative regulatory function by ectopic expression of hFoxp3 gene Transplantation, June 12, 2013    Review Article

7 The genetics and genomics of thoracic aortic disease Full Text Annals of Cardiothoracic Surgery, June 12, 2013

8 International rates of breast reconstruction after prophylactic mastectomy in brca1 and brca2 mutation carriers Annals of Surgical Oncology, June 10, 2013    Clinical Article

9 Effects of botulinum toxin Type A on expression of genes in keloid fibroblasts Aesthetic Surgery Journal, June 6, 2013    Clinical Article

10 MMP-2 is a disease modifying gene in Primary Sclerosing Cholangitis Liver International, June 5, 2013    Review Article

11 Alterations of naïve and memory B cell subsets are associated with risk of rejection and infection in heart recipients Transplant International, June 3, 2013    Clinical Article

12 Propofol protects against nitrosative stress-induced apoptotic insults to cerebrovascular endothelial cells via an intrinsic mitochondrial mechanism Surgery, June 3, 2013    Review Article

13 Gene set enrichment analysis identifies key innate immune pathways in primary graft dysfunction after lung transplantation American Journal of Transplantation, June 3, 2013    Review Article

14 Risk of metachronous colon cancer following surgery for rectal cancer in mismatch repair gene mutation carriers Annals of Surgical Oncology, May 31, 2013    Clinical Article

15 A novel germline kit mutation (p.l576p) in a family presenting with juvenile onset of multiple gastrointestinal stromal tumors, skin hyperpigmentations, and esophageal stenosis American Journal of Surgical Pathology , May 30, 2013

16 Fat grafting as a vehicle for the delivery of recombinant adenoassociated viral vectors to achieve gene modification of muscle flaps Annals of Plastic Surgery, May 29, 2013    Clinical Article

17 Molecular transplantation pathology: the interface between molecules and histopathology Current Opinion in Organ Transplantation, May 29, 2013    Review Article

18 Dynamic trends in cardiac surgery: why the logistic EuroSCORE is no longer suitable for contemporary cardiac surgery and implications for future risk models European Journal of Cardio-Thoracic Surgery, May 28, 2013    Review Article

19 Multicenter experience using telaprevir or boceprevir with peginterferon and ribavirin to treat hepatitis C genotype 1 after liver transplantation Liver Transplantation, May 28, 2013    Clinical Article

20 Understanding pancreatic cancer genomes Journal of Hepato-Biliary-Pancreatic Sciences, May 23, 2013    Clinical Article

50 available pages FirstPrevious 1 2 3 4 5 6 7 8 9 10 Next Last

Clinical Pearls in Surgery

Highlights in Surgery

Epidural anesthesia reduces post-CABG pain

As published in the Journal of Cardiac Surgery, thoracic epidural anesthesia (TEA) plus general anesthesia (GA) is superior to GA alone in managing post-operative CABG pain. Forty patients undergoing elective CABG were randomized to receive TEA (0.25% bipivacaine [10-20 mg/h]) intra-operatively and for 24 h post-operatively plus GA or GA alone. Post-operative pain at rest and with coughing was significantly less for up to 1 month post-operatively in the TEA + GA group compared to the GA alone group. Furthermore, analgesic use, mechanical ventilation time, ICU stay time, and hospital stay time were reduced in the TEA + GA group compared to the GA alone group.

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NT-proBNP predicts outcome following emergent surgery

As published in the British Journal of Anaesthesia, measurement of N-terminal pro B-type natruiretic peptide (NT-proBNP) pre- and post-operatively predicts outcome in patients > 50 years of age (n=297) undergoing emergent non-cardiac surgery. A pre-operative NT-proBNP > 725 pg/ml was associated with a 4.8-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. Similarly, a post-operative NT-proBNP > 1600 pg/ml was associated with a 4.0-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. A pre-operative NT-proBNP > 1740 pg/ml was associated with a 6.9 RR for major adverse cardiac events during the post-operative hospital stay.

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Increased risk of skin cancer in RCC treated with multikinase inhibitors

As published in Dermatologic Surgery, RCC patients (n=69) treated with multikinase inhibitors are at increased risk for squamous cell carcinomas and basal cell carcinomas. After a median treatment of 13.5 months, 13.5% and 6.3% of patients treated with sorafenib and sunitinib developed skin cancer, respectively.

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Most Popular Surgery Articles

Last month's top read Top Articles of 2012

1 Stapled versus hand-sewn anastomoses in emergency general surgery: A retrospective review of outcomes in a unique patient population The Journal of Trauma and Acute Care Surgery, April 29, 2013    Evidence Based Medicine    Review Article

2 Independent Validation of a Prognostic Genomic Signature (ColoPrint) for Patients With Stage II Colon Cancer Annals of Surgery, May 20, 2013

3 Understanding pancreatic cancer genomes Journal of Hepato-Biliary-Pancreatic Sciences, May 23, 2013

4 Cell Therapy of Peripheral Arterial Disease Circulation Research, April 29, 2013

5 Plasmacytoid Dendritic Cells: No Longer an Enigma and Now Key to Transplant Tolerance? American Journal of Transplantation, May 1, 2013    Review Article

6 Minimal access surgery compared with medical management for gastro-oesophageal reflux disease: five year follow-up of a randomised controlled trial (REFLUX) British Medical Journal, April 23, 2013

7 Impact of KRAS, BRAF and PI3KCA mutations in rectal carcinomas treated with neoadjuvant radiochemotherapy and surgery BMC Cancer, April 30, 2013    Free full text    Review Article

8 Dynamic trends in cardiac surgery: why the logistic EuroSCORE is no longer suitable for contemporary cardiac surgery and implications for future risk models European Journal of Cardio-Thoracic Surgery, May 28, 2013    Review Article

9 STAT3 Pathway Is Activated in ALK-positive Large B-cell Lymphoma Carrying SQSTM1-ALK Rearrangement and Provides a Possible Therapeutic Target American Journal of Surgical Pathology , May 3, 2013

10 Mitogen-activated protein kinases regulate vascular reactivity after hemorrhagic shock through myosin light chain phosphorylation pathway The Journal of Trauma and Acute Care Surgery, April 3, 2013

11 Mid-term outcomes following endovascular re-intervention for iliac artery in-stent restenosis Catheterization and Cardiovascular Interventions, May 1, 2013

12 Persistent stapedial arteries in human: from phylogeny to surgical consequences Surgical and Radiologic Anatomy, May 14, 2013    Review Article

13 Properdin and Factor H: Opposing Players on the Alternative Complement Pathway See-Saw Frontiers in Immunology, May 7, 2013    Review Article

14 Fat grafting as a vehicle for the delivery of recombinant adenoassociated viral vectors to achieve gene modification of muscle flaps Annals of Plastic Surgery, May 29, 2013

15 Insulin independence after islet transplantation through an indwelling catheter in the right gastric vein The International Journal of Artificial Organs, May 21, 2013    Review Article

16 Intraoperative Management and Repair of Bile Duct Injuries Sustained during 10,123 Laparoscopic Cholecystectomies in a High-Volume Referral Center Journal of the American College of Surgeons, March 25, 2013

Indexed Journals in Surgery: Surgery, Journal of the American College of Surgeons, Annals of Surgerymore

Other Topics in Surgery

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