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Surgery - Basic Science/Genetics News & Articles

MDLinx Surgery is your ultimate resource for the latest General Surgery and subspecialty surgery news articles published in over 2,000 peer-reviewed medical journals and popular press. Our diligent team of medical editor’s rank sort and summarize Surgery news articles with topics ranging from: Cardiac Surgery, Critical Care, Vascular, Thoracic, Peds Surgery, Neurosurgery and much more. On this page you may also find bonus content that includes articles highlighted by our physician editor, D. Scott Cunningham, MD, PhD, that are “must-read “ as well as clinical pearls taken from our Smartest Doc quiz competition.

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Articles

Latest Full Text Articles (20)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

901 MEK mediates the novel cross talk between TNFR2 and TGF-EGFR in enhancing vascular endothelial growth factor secretion from human mesenchymal stem cells Surgery, July 14, 2009

902 Both endogenous and exogenous testosterone decrease myocardial STAT3 activation and SOCS3 expression after acute ischemia and reperfusion Surgery, July 14, 2009

903 Mitochondrial Genomic Instability in Colorectal Cancer: No Correlation to Nuclear Microsatellite Instability and Allelic Deletion of hMSH2, hMLH1, and p53 Genes, but Prediction of Better Survival for Dukes Stage C Disease Annals of Surgical Oncology, July 13, 2009

904 Inhibition of Phosphatidylinositol 3-Kinase/Akt Signaling Suppresses Tumor Cell Proliferation and Neuroendocrine Marker Expression in GI Carcinoid Annals of Surgical Oncology, July 13, 2009

905 Prognostic role of myeloid cell leukemia-1 protein (Mcl-1) expression in human gastric cancer Journal of Surgical Oncology, July 8, 2009

906 Increased expression of hyaluronic acid binding protein 1 is correlated with poor prognosis in patients with breast cancer Journal of Surgical Oncology, July 7, 2009

907 Serum p53 Antibody as Tumor Marker for Follow-Up of Colorectal Cancer After Curative Resection Annals of Surgical Oncology, July 6, 2009

908 Regulation of Matrix Contraction in Chronic Venous Disease European Journal of Vascular and Endovascular Surgery, July 6, 2009

909 Matrix Metalloproteinase-2 Gene Variants and Abdominal Aortic Aneurysm European Journal of Vascular and Endovascular Surgery, July 6, 2009

910 Allospecific CD154+ T cells identify rejection-prone recipients after pediatric small-bowel transplantation Surgery, July 6, 2009

911 Neurosecurity: security and privacy for neural devices Full Text Neurosurgical Focus, July 2, 2009    Continuing Medical Education

912 Human cortical prostheses: lost in translation? Full Text Neurosurgical Focus, July 2, 2009    Continuing Medical Education

913 Comprehensive Analysis of the Clinical Significance of Inducing Pluripotent Stemness-Related Gene Expression in Colorectal Cancer Cells Annals of Surgical Oncology, July 1, 2009

914 T regulatory cells in xenotransplantation Xenotransplantation, July 1, 2009

915 A Case of Primary Synovial Sarcoma of the Thorax With a Variant SYT-SSX1 Fusion Transcript Full Text Annals of Thoracic Surgery, June 30, 2009

916 Soluble Human Leukocyte Antigen class I antigen and interleukin-12 in hepatectomized patients ANZ Journal of Surgery, June 29, 2009

917 IgG4-related Sclerosing Mastitis: Description of a New Member of the IgG4-related Sclerosing Diseases American Journal of Surgical Pathology , June 26, 2009

918 REG1A predicts recurrence in stage Ta/T1 bladder cancer European Journal of Surgical Oncology, June 26, 2009

919 Patterns of expression and function of the p75NGFR protein in pancreatic cancer cells and tumours European Journal of Surgical Oncology, June 26, 2009

920 Basal Cytokeratin and Epidermal Growth Factor Receptor Expression Are Not Predictive of BRCA1 Mutation Status in Women With Triple-negative Breast Cancers American Journal of Surgical Pathology , June 26, 2009

50 available pages First Previous 41 42 43 44 45 46 47 48 49 50 Next Last

Clinical Pearls in Surgery

Highlights in Surgery

Epidural anesthesia reduces post-CABG pain

As published in the Journal of Cardiac Surgery, thoracic epidural anesthesia (TEA) plus general anesthesia (GA) is superior to GA alone in managing post-operative CABG pain. Forty patients undergoing elective CABG were randomized to receive TEA (0.25% bipivacaine [10-20 mg/h]) intra-operatively and for 24 h post-operatively plus GA or GA alone. Post-operative pain at rest and with coughing was significantly less for up to 1 month post-operatively in the TEA + GA group compared to the GA alone group. Furthermore, analgesic use, mechanical ventilation time, ICU stay time, and hospital stay time were reduced in the TEA + GA group compared to the GA alone group.

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NT-proBNP predicts outcome following emergent surgery

As published in the British Journal of Anaesthesia, measurement of N-terminal pro B-type natruiretic peptide (NT-proBNP) pre- and post-operatively predicts outcome in patients > 50 years of age (n=297) undergoing emergent non-cardiac surgery. A pre-operative NT-proBNP > 725 pg/ml was associated with a 4.8-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. Similarly, a post-operative NT-proBNP > 1600 pg/ml was associated with a 4.0-fold RR of non-fatal MI, acute heart failure, or death between surgery and the 3-year post-operative follow up. A pre-operative NT-proBNP > 1740 pg/ml was associated with a 6.9 RR for major adverse cardiac events during the post-operative hospital stay.

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Increased risk of skin cancer in RCC treated with multikinase inhibitors

As published in Dermatologic Surgery, RCC patients (n=69) treated with multikinase inhibitors are at increased risk for squamous cell carcinomas and basal cell carcinomas. After a median treatment of 13.5 months, 13.5% and 6.3% of patients treated with sorafenib and sunitinib developed skin cancer, respectively.

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