Oral supplementation of branched-chain amino acids reduces early recurrence after hepatic resection in patients with hepatocellular carcinoma: a prospective study
Surgery Today, 08/20/2012
Ichikawa K et al. – Oral supplementation of branched–chain amino acids (BCAA) reduces early recurrence after hepatic resection in patients with HCC. This treatment regimen offers potential benefits for clinical use in such patients, even in cases with a well–preserved preoperative liver function.Methods
- Fifty–six patients were randomly assigned to receive either BCAA supplementation (Livact group, n = 26) or a conventional diet (Control group, n = 30).
- Twenty–six patients in the BCAA group were treated orally for 2 weeks before and 6 months after hepatic resection.
- Postoperative tumor recurrence was continuously evaluated in all patients by measuring various clinical parameters.
- There was no significant difference in the overall survival rate between the two patient groups; however, the recurrence rate at 30 months after surgery was significantly better in the Livact group in comparison to the Control group.
- Interestingly, the tumor markers, such as AFP and PIVKA–II, significantly decreased at 36 months after liver resection in the Livact group in comparison to the Control group.