Toll-like receptor 9 agonists increase Cyclin D1 expression partly through the activation of AP-1 in human oral squamous cell carcinoma cells
Cancer Science, 08/03/2012
Min R et al. – The results demonstrate that CpG–oligodeoxynucleotides (CpG–ODN) stimulate tumor cell proliferation via TLR–9 mediated AP–1 activated Cyclin D1 expression in OSCC HB cells. Pharmacologic inhibition of the Toll–like receptors (TLRs)–9/AP–1/Cyclin D1 pathway may be a new therapeutic approach for prevention as well as treatment of OSCC in the future.