Bimonthly Regimen of High-Dose Leucovorin, Infusional 5-Fluorouracil, Epirubicin and Cisplatin (Modified ECF) as Adjuvant Chemotherapy in Resected Gastric Adenocarcinoma
Unek IT et al. – A de Gramont regimen in combination with cisplatin and epirubicin (modified ECF) regimen may be an effective and convenient treatment with tolerable toxicities for the adjuvant treatment of gastric cancer. It may provide an alternative regimen to the standard ECF when a continuous ambulatory infusion pump is not feasible or not preferred by the patient.Methods
- Forty-eight patients with curatively resected gastric cancer were treated.
- Each 2-week cycle consisted of epirubicin (50mg/m2), cisplatin (50mg/m2), 5-fluorouracil (5-FU) IV bolus (400mg/m2) and 5-FU IV (2,400mg/m2) over 46h plus leucovorin IV (400mg/m2) over 2h.
- Postoperative chemoradiotherapy was also administered to the patients when indicated.
- The authors retrospectively reviewed the patients who were treated with modified ECF.
- The median disease-free survival (DFS) was 40.7months and the 1-, 3- and 5-year DFS rates were 78.5, 55.7 and 44.6%, respectively.
- The most common grade 3–4 toxicities were hematological and gastrointestinal.