Role of osteopontin in the development of neointimal hyperplasia in vein grafts

European Journal of Cardio-Thoracic Surgery, 05/31/2012

Early induction of OPN in vein grafts may contribute to the subsequent increase in MMPs activities as well as vascular smooth muscle cell proliferation. Therefore, OPN could play an important role in the development of neointimal hyperplasia in venous conduits after coronary artery bypass grafting.

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