Effects of preoperative aspirin in coronary artery bypass grafting: A double-blind, placebo-controlled, randomized trial
The Journal of Thoracic and Cardiovascular Surgery,  Clinical Article

Deja MA et al. – Performing coronary grafts on aspirin is associated with increased postoperative bleeding but may decrease the long–term hazard of coronary events.

Methods
  • This randomized, double–blind, parallel–group, single–center trial involved patients with stable coronary artery disease who were assigned to receive either 300 mg of aspirin or placebo the night before coronary bypass surgery.
  • Using a random digit table, patients were allocated to receive the tablet from 1 of the 40 coded bottles containing either aspirin or placebo.
  • Patients, surgeons, anesthetists, and investigators were all masked to treatment allocation.
  • The primary safety end points were as follows: more than 750 mL of bleeding during the first postoperative 12 hours and more than 1000 mL of total discharge from the chest drains.
  • The secondary efficacy end point was a composite of cardiovascular death, myocardial infarction, or repeat revascularization.

Results
  • A total of 390 patients were allocated to aspirin (387 analyzed) and 399 to placebo (396 analyzed).
  • The follow–up median was 53 months.
  • Fifty–four placebo recipients and 86 aspirin recipients bled more than 750 mL in the first 12 hours (odds ratio [OR], 1.81; 95% confidence interval [CI], 1.25–2.63), while total chest drain discharge was above 1000 mL in 96 placebo and 131 aspirin recipients (OR, 1.60; 95% CI, 1.17–2.18).
  • Preoperative aspirin decreased the long–term hazard of nonfatal coronary event (infarction or repeat revascularization)–hazard ratio (HR), 0.58 (95% CI, 0.33–0.99)–and tended to decrease the hazard of a major cardiac event (cardiovascular death, infarction, or repeat revascularization–HR, 0.65 [95% CI, 0.41–1.03]).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Surgery

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Surgery Articles

1 Laparoscopic sleeve gastrectomy versus laparoscopic Roux-en-Y gastric bypass: A single center experience with 2 years follow-up Obesity Surgery, August 8, 2014    Clinical Article

2 Noninvasive body contouring: biological and aesthetic effects of low-frequency, low-intensity ultrasound device Aesthetic Plastic Surgery, September 12, 2014    Clinical Article

3 Retrospective analysis of never events in panniculectomy and abdominoplasty patients and their financial implications Annals of Plastic Surgery, September 17, 2014    Review Article

4 Long intestinal tube splinting really prevent recurrence of postoperative adhesive small bowel obstruction? A study of 1071 cases The American Journal of Surgery, July 23, 2014    Clinical Article

5 Long-term follow-up after bariatric surgery: a systematic review JAMA, September 9, 2014    Evidence Based Medicine    Review Article

6 Endoscopic gastric volume reduction with a novel articulating plication device is safe and effective in the treatment of obesity Gastrointestinal Endoscopy, September 19, 2014    Clinical Article

7 Morbidity of loop ileostomy closure after restorative proctocolectomy for ulcerative colitis and familial adenomatous polyposis: a systematic review Journal of Gastrointestinal Surgery, September 24, 2014    Evidence Based Medicine    Review Article    Clinical Article

8 Bariatric surgery in elderly patients. A comparison between gastric banding and sleeve gastrectomy with five years of follow up International Journal of Surgery, August 26, 2014    Clinical Article

9 Transumbilical laparoscopic-assisted appendectomy is associated with lower costs compared to multiport laparoscopic appendectomy Journal of Pediatric Surgery, September 29, 2014    Review Article

10 Clinical efficacy of bariatric surgery versus liraglutide in patients with type 2 diabetes and severe obesity: a 12-month retrospective evaluation Acta Diabetologica, September 15, 2014    Clinical Article

11 Demonstrating the benefits of transversus abdominis plane blocks on patient outcomes in laparoscopic colorectal surgery: review of 200 consecutive cases Journal of the American College of Surgeons, September 23, 2014    Review Article

12 Simplifying the management of caudal septal deviation in rhinoplasty Plastic and Reconstructive Surgery, September 3, 2014    Clinical Article

13 Abdominoplasty-derived dermal-fat graft augmentation gluteoplasty Aesthetic Surgery Journal, August 25, 2014    Review Article
Exclusive Author Commentary

14 The influence of preexisting lower extremity edema and venous stasis disease on body contouring outcomes Annals of Plastic Surgery, September 25, 2014    Clinical Article

15 Laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy for the treatment of morbid obesity. A prospective study with 5 years of follow-up Obesity Surgery, July 14, 2014    Clinical Article

16 Outcome of duct-to-duct vs. Roux-en-Y hepaticojejunostomy biliary anastomoses in below 15-kg pediatric liver transplant recipients Pediatric Transplantation, September 5, 2014    Review Article    Clinical Article

17 Single versus double Roux-en-Y reconstruction techniques in pancreaticoduodenectomy: a comparative single-center study World Journal of Surgery, September 11, 2014    Clinical Article

18 “Supersize” Panniculectomy: indications, technique, and results Annals of Plastic Surgery, September 16, 2014    Review Article

19 The lateral crural rein flap: A novel technique for management of tip rotation in primary rhinoplasty Aesthetic Surgery Journal, September 10, 2014    Clinical Article

20 Perioperative and postoperative outcomes of perforated diverticulitis Hinchey II and III: Open Hartmans procedure vs. laparoscopic lavage and drainage in the elderly International Journal of Surgery, September 9, 2014    Clinical Article

Indexed Journals in Surgery: Surgery, Journal of the American College of Surgeons, Annals of Surgerymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close