Zhao WC et al. – Multiple hepatocellular carcinomas (HCC) patients within the University of California, San Francisco (UCSF) criteria benefit from curative resection. Expansion of curative treatment is justified.Methods
- Clinical and survival data of 162 multiple–HCC patients in Child–Pugh class A who underwent curative resection were retrospectively reviewed.
- Prognostic risk factors were analyzed using univariate and multivariate analyses.
- UCSF criteria were shown to independently predict overall and disease–free survival.
- In patients within the UCSF criteria, 3–year overall and disease–free survivals were significantly better than in those exceeding the UCSF criteria (68 vs. 34 % and 54 vs. 26 %, respectively; both p < 0.001).
- There were no significant differences in 3–year overall and disease–free survival between patients within the UCSF criteria but exceeding the BCLC early stage and patients with BCLC early–stage disease (71 vs. 66 %, p = 0.506 and 57 vs. 50 %, p = 0.666, respectively).
- Tumors within the UCSF criteria were associated with a lower incidence of high–grade tumor (p = 0.009), microvascular invasion (p = 0.005), 3–month death (p = 0.046), prolonged Pringle’s maneuver (p = 0.005), and surgical margin <0.5 cm (p < 0.001) than those exceeding the UCSF criteria.
- Tumors within the UCSF criteria but exceeding the BCLC early stage had invasiveness and surgical difficulty similar to those within the BCLC early–stage criteria.