Oxidative Stress Response After Laparoscopic Versus Conventional Sigmoid Resection: A Randomized, Double-blind Clinical Trial

Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, 06/08/2012

There was a significant drop in ascorbic acid at 1 hour and 6 hours after the first abdominal incision (P=0.002) for all 19 patients. Laparoscopic surgery was not found to be associated with reduced oxidative stress.

  • Surgery is accompanied by a surgical stress response, which results in increased morbidity and mortality.
  • Oxidative stress is a part of the surgical stress response.
  • Minimally invasive laparoscopic surgery may result in reduced oxidative stress compared with open surgery.
  • Nineteen patients scheduled for sigmoid resection were randomly allocated to open or laparoscopic sigmoid resection in a double–blind, prospective clinical trial.
  • Three biochemical markers of oxidative stress (malondialdehyde, ascorbic acid, and dehydroascorbic acid) were measured at 6 different time points (preoperatively, 1 h, 6 h, 24 h, 48 h, and 72 h postoperatively).
  • There were no statistical significant differences between laparoscopic and open surgery for any of the 3 oxidative stress parameters.
  • Malondialdehyde was reduced 1 hour postoperatively (P<0.001) for all 19 patients.

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