The correlations between the expression of FGFR4 protein and clinicopathological parameters as well as prognosis of gastric cancer patients
Journal of Surgical Oncology, 05/15/2012Ye YW et al.
High expression of FGFR4 protein, accelerating the progression of advanced GC, might be associated with a poor prognosis in patients with advanced FC.
Ninety–four paraffin–embedded tumor specimens were obtained from Cancer Hospital, Fudan University.
The expression of FGFR4 as well as p53, p21, EGFR, neu, c–myc, and PCNA were detected by immunohistochemical method.
Then, correlation analysis and survival analysis were performed.
The expression rate of FGFR4 protein in GC tissues and normal stomach tissues was 93.6% and 30.8%, respectively (P=0.000).
The expression of FGFR4 was positively correlated with the expression of p21, neu and PCNA (P–value was 0.009, 0.012, and 0.018, respectively).
Subgroup analysis showed that compared to low expression group, the prognosis of patients with III/IV stage and negative expression of p21 in high expression group of FGFR4 were worse (P=0.048, 0.041, respectively).
Multivariate analysis showed that TNM stage was the independent prognostic factor in high expression group (HR, 11.593; 95% CI, 3.532–18.058; P=0.000).
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