Expression of estrogen receptors in gastric cancer and their clinical significance

Journal of Surgical Oncology, 04/04/2012

The results suggest that the presence of ER–β in gastric cancer could have a protective effect against invasiveness of gastric cancer. Further studies are needed to clarify the role of ER–β in gastric cancers.

Methods

  • ER–α, ER–β proteins extracted from normal stomach, gastric cancer tissues, and cultured gastric cancer cells (KATO–III, mkn28, mkn45, and mkn74) were assessed by Western blot analysis.
  • The clinical significance of ER–β was explored using tissue microarray methods and immunohistochemical staining of specimens from 148 gastric cancers.

Results

  • Both ER–α and β protein expression were noted in normal and gastric cancer tissues.
  • However, in cultured gastric cells, only ER–β was noted in mkn28 and mkn74.
  • Of 148 gastric cancers, 67 (45.3%) were ER–β positive.
  • The ER–β positive group was associated with lower tumor stage, Lauren's intestinal type, negative perineural invasion, and free of recurrence.
  • The ER–β positive group had a better 3–year survival compared with the negative group in survival analysis.

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