Expression of estrogen receptors in gastric cancer and their clinical significance
Journal of Surgical Oncology, 04/04/2012Ryu WS et al.
The results suggest that the presence of ER–β in gastric cancer could have a protective effect against invasiveness of gastric cancer. Further studies are needed to clarify the role of ER–β in gastric cancers.
ER–α, ER–β proteins extracted from normal stomach, gastric cancer tissues, and cultured gastric cancer cells (KATO–III, mkn28, mkn45, and mkn74) were assessed by Western blot analysis.
The clinical significance of ER–β was explored using tissue microarray methods and immunohistochemical staining of specimens from 148 gastric cancers.
Both ER–α and β protein expression were noted in normal and gastric cancer tissues.
However, in cultured gastric cells, only ER–β was noted in mkn28 and mkn74.
Of 148 gastric cancers, 67 (45.3%) were ER–β positive.
The ER–β positive group was associated with lower tumor stage, Lauren's intestinal type, negative perineural invasion, and free of recurrence.
The ER–β positive group had a better 3–year survival compared with the negative group in survival analysis.
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