It has been repeatedly shown that a subset of CD4+ T cells that constitutively express CD25 on their surface plays arole in the maintenanceof self-tolerance. They maydirectlyorindirectly affect the development of autoimmunity in susceptible mice and humans. In this study, we examine the relationship between the percentage of peripheral CD4+CD25+ T cells and the state of disease in spontaneous models of autoimmune disease
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