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Study of the role of leukotriene B4 in abnormal function of human subchondral osteoarthritis osteoblasts: Effects of cyclooxygenase and/or 5-lipoxygenase inhibition
Arthritis & Rheumatism, 07/15/02

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Conclusion: Licofelone inhibits the production of PGE2 and LTB4. Selective effects of licofelone on AP and osteocalcin occur via its role on LTB4 production. Because LTB4 can modify cell biomarkers in OA and normal osteoblasts, our results suggest licofelone could modify abnormal bone remodeling in OA

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