Rheumatology Medical News

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Blood dendritic cells in systemic lupus erythematosus exhibit altered activation state and chemokine receptor function
Annals of Rheumatic Diseases, 11/09/09

Gerl V et al. – The phenotypic and migratory disturbances observed in SLE blood DCs could result in altered distribution of DCs in peripheral tissues, contributing to dysregulated immune responses and autoimmunity.

Methods

Plasmacytoid DCs (pDCs), myeloid DCs (mDCs) and monocytes from SLE patients, healthy volunteers, and healthy volunteers immunized with tetanus/diphtheria examined by flow cytometry for expression of subset specific antigens (BDCA-2, CD11c, CD14, HLA-DR), activation/maturation markers (CD83, CD86, CD40, BLyS) and chemokine receptors (CCR1, CCR5, CCR7, ChemR23)
Migratory capacity to chemokine receptors investigated in vitro using chemokines RANTES, CCL19 and chemerin

Results

SLE monocytes and myeloid DCs had higher CD86 and BLyS expression levels
ChemR23 expression lower in SLE plasmacytoid and myeloid DCs (p = 0.03). Basal (p= 0.004) and CCL19-specific migration levels (p=0.004) were higher in SLE plasmacytoid DCs
Altered DC function in SLE had no correlative changes in chemokine receptor expression whereas immunization-induced blood DC migration patterns in healthy donors accompanied by changes in chemokine receptor expression

<< Previous
Osteonecrosis of the jaw correlated to bisphosphonate therapy in...

Next >>
Circulating mesenchymal stem cells with abnormal osteogenic...