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Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: Inhibition of interleukin-1beta-induced nuclear factor-kappaB-mediated inflammation and apoptosis
Arthritis Research & Therapy, 11/10/09

Csaki C et al. – We propose that combining these natural compounds may be a useful strategy in OA therapy as compared to separate treatment with each individual compound.

• Investigated the potential synergistic effects of curcumin and resveratrol on interleukin (IL)-1beta-stimulated human chondrocytes in vitro using immunoblotting and electron microscopy
• Modulatory effects of curcumin and resveratrol on IL-1beta-induced expression of cartilage-specific matrix and pro-inflammatory enzymes are mediated in part by cartilage specific transcription factor Sox-9

• Treatment with curcumin and resveratrol suppressed NF-kappaB regulated gene products involved in inflammation (cyclooxygenase-2 (COX-2) and matrix metalloproteinase (MMP)-3, -9, vascular endothelial growth factor (VEGF)), inhibited apoptosis (Bcl-2, Bcl-xL, and tumor necrosis factor receptor-associated factor 1 (TRAF1)) and prevented activation of caspase-3. IL-1beta-induced NF-kappaB activation was suppressed directly by cocktails of curcumin and resveratrol through inhibition of Ikappakappa- and proteasome-activation, inhibition of Ikappa-Balpha phosphorylation and degradation and inhibition of nuclear translocation of NF-kappaB

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