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Blank M et al. – Environmental factors are capable of triggering the expression of human endogenous retroviruses and induce an autoimmune response. Infection can promote the expression of human endogenous retroviruses by molecular mimicry or by functional mimicry. In the current review the authors summarize the current knowledge on infections, molecular mimicry, cross–reactivity and epigenetics contribution for trigger human endogenous retroviruses expression and pathogenesis in lupus patients.

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