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Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis
Arthritis & Rheumatism, 11/09/09
Uz E et al. – Findings of the present study indicate that skewed XCI may be a risk factor for the occurrence of autoimmune disorders, including JIA.
Methods- Polymorphic repeat in androgen receptor gene genotyped to determine XCI status in 81 female patients with JIA (21 with polyarticular disease and 60 with oligoarticular disease)
- 211 healthy female controls
- DNA obtained from venous blood samples used for analysis
- Informative data obtained on 62 JIA patients and 155 controls
- Skewed XCI observed in 14 patients (22.6%) and 11 controls (7.1%)
- Extreme skewing apparent in 8 patients (12.9%) and 2 controls (1.3%)
Today in Autoimmune/Heritable...keeping you current
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Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjogrens syndrome
Annals of Rheumatic Diseases, 11/23/09
Genetic background of systemic sclerosis: autoimmune genes take centre stage
Rheumatology, 11/23/09
Identification of anti-prothrombin antibodies in the anti-phospholipid syndrome that display the prothrombinase activity
Rheumatology, 11/20/09
Today in Basic Science/Genetics...keeping you current
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Low plasma levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF &alpha), and vascular endothelial growth factor (VEGF) in patients with alpha1-antitrypsin deficiency-related fibromyalgia
Clinical Rheumatology, 11/24/09
Lipid peroxidation, glutathione, vitamin E, and antioxidant enzymes in synovial fluid from patients with osteoarthritis
International Journal of Rheumatic Diseases, 11/24/09
Vaspin and omentin: new adipokines differentially regulated at the site of inflammation in rheumatoid arthritis
Annals of Rheumatic Diseases, 11/24/09
Today in Pediatric Rheumatology...keeping you current
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The detection of subclinical synovitis by ultrasound in oligoarticular juvenile idiopathic arthritis: A pilot study
Rheumatology, 11/24/09
Disease activity and disability in children with juvenile idiopathic arthritis one year following presentation to paediatric rheumatology. Results from the Childhood Arthritis Prospective Study
Rheumatology, 11/23/09
Acute epiglottitis as the initial presentation of pediatric Systemic Lupus Erythematosus
Pediatric Rheumatology, 11/10/09
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