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See Latest ArticlesB lymphocyte stimulator expression in pediatric systemic lupus erythematosus and juvenile idiopathic arthritis patients
Arthritis & Rheumatism, 11/04/09
Hong SD et al. – Plasma BLyS protein and blood leukocyte BLyS mRNA levels are elevated in pediatric SLE. The correlation of plasma BLyS protein levels with disease activity points to BLyS as a candidate therapeutic target in pediatric SLE. Plasma BLyS protein levels are normal in JIA despite elevated blood leukocyte BLyS mRNA levels.The absence of correlation between either of the BLyS parameters and disease activity in JIA calls for circumspection prior to assigning BLyS as a candidate therapeutic target in this disorder.
Methods- Blood samples collected from patients with pediatric SLE (n = 56) and patients with JIA (n = 54) at the beginning and end of a 6-month interval were analyzed for plasma BLyS protein levels by enzyme-linked immunosorbent assay and for blood leukocyte full-length BLyS and BLyS messenger RNA (mRNA) levels by quantitative real-time polymerase chain reaction (normalized to 18S expression)
- In pediatric SLE, plasma BLyS protein and blood leukocyte BLyS mRNA levels were each significantly elevated, and plasma BLyS protein levels, but not blood leukocyte BLyS mRNA levels, were correlated with disease activity
- Plasma BLyS protein levels were normal in JIA despite blood leukocyte BLyS mRNA levels being elevated to degrees similar to those in pediatric SLE
- Among JIA patients, neither BLyS parameter was correlated with disease activity
- In both pediatric SLE and JIA, the BLyS expression profiles remained stable at 6 months
Today in Basic Science/Genetics...keeping you current
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Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjogrens syndrome
Annals of Rheumatic Diseases, 11/23/09
Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus
Annals of Rheumatic Diseases, 11/22/09
Circulating microparticles remain associated with complement activation despite intensive anti-inflammatory therapy in early rheumatoid arthritis
Annals of Rheumatic Diseases, 11/22/09
Today in Pediatric Rheumatology...keeping you current
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The incidence of juvenile rheumatoid arthritis in Quebec: A population data-based study
Pediatric Rheumatology, 11/22/09
Disease activity and disability in children with juvenile idiopathic arthritis one year following presentation to paediatric rheumatology. Results from the Childhood Arthritis Prospective Study
Rheumatology, 11/22/09
Monitoring methotrexate toxicity in juvenile idiopathic arthritis
Journal of Rheumatology, 11/18/09
Today in Systemic Lupus (SLE)...keeping you current
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Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus
Annals of Rheumatic Diseases, 11/22/09
Analysis of correlations between selected endothelial cell activation markers, disease activity, and nailfold capillaroscopy microvascular changes in SLE patients
Clinical Rheumatology, 11/17/09
Liver enzyme abnormalities in systemic lupus erythematosus: A focus on toxic hepatitis
Rheumatology International, 11/11/09
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