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Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation
Arthritis & Rheumatism, 11/03/09

Addison S et al. – Synovial fluid COMP levels correlated strongly with 2 indicators of knee joint inflammation: early–phase bone scintigraphic findings and synovial fluid volume. Serum COMP levels correlated with total–body joint disease severity as determined by late–phase bone scintigraphy, supporting the hypothesis that whole–body bone scintigraphy is a means of quantifying the total–body burden of OA for systemic biomarker validation.

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