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Immune changes in post-menopausal osteoporosis: The Immunos study
Osteoporosis International, 11/03/09

Breuil V et al. – These results suggest that, regardless of age and estrogen status, postmenopausal OP is associated with immune changes, highlighting a possible role of IFN-&Upsilon in the pathophysiology of OP and reporting, for the first time, changes in several B lymphocyte populations. These alterations may reflect the frailty observed after fracture, providing new insight into the mechanisms of morbidity and mortality associated with OP fractures.

Methods

Analyzed surface markers of peripheral B, CD4+ and CD8+ lymphocytes and cytokine secretion in supernatants of these cells cultured with or without stimulation
Body composition assessed by dual energy X-ray absorptiometry

Results

2 groups were similar for age and estrogen level
OP women had significantly lower BMI, fat mass, and lean mass
Number of CD19+, CD19+/CD27+, CD19+/CD27+/CD5?/CD38+ and CD19+/CD27+/RANK+, CD4+/CD27+/CD45RA?/RANK+, and CD4+/CD27+/CD45RA?/CD28+ lower in OP women and positively correlated to BMD
In OP women, under basal conditions, CD4+ secreted less IFN-? and B lymphocytes more granulocyte macrophage colony-stimulating factor (GM-CSF)
GM-CSF positively correlated to fracture rate and negatively to BMD

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