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Does rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease? A prospective study
Arthritis Care and Research , 11/03/09

Peters MJL et al. – The risk of CVD in RA was significantly elevated compared with the general population, and comparable with the magnitude of risk in type 2 DM.

Methods

3-year incidence rate of CVD determined in prospective cohort (the Cardiovascular Research and Rheumatoid Arthritis Study) of 353 outpatients with RA, and compared with that in 1,852 population-based cohort study participants (155 had type 2 DM)
Investigated fatal and nonfatal CVD (according to International Classification of Diseases, Ninth Revision criteria) and used Cox proportional hazards models to assess incidence of CVD in RA, type 2 DM, and general population

Results

3-year incidence of CVD 9.0% in patients with RA and 4.3% in general population, corresponding with incidence rate of 3.30 per 100 patient-years (95% confidence interval [95% CI] 2.08-4.25) and 1.51 per 100 person-years (95% CI 1.18-1.84), respectively
Compared with general population, the age- and sex-adjusted hazard ratio (HR) for RA was 1.94 (95% CI 1.24-3.05)
Neither exclusion of patients with prior CVD at baseline nor adjustment for cardiovascular risk factors significantly influenced this
Compared with the nondiabetic population, nondiabetic patients with RA and those with type 2 DM had comparable HRs, 2.16 (95% CI 1.28-3.63) and 2.04 (95% CI 1.12-3.67), respectively

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Increased incidence of cardiovascular events in patients with antineutrophil cytoplasmic antibody-associated vasculitides: A matched-pair cohort study
Arthritis & Rheumatism, 11/05/09 Relevance Score: 71%

Chronic renal insufficiency, cardiovascular disease and mortality in women: a causal relationship or coincidence?
Women's Health, 11/02/09 Relevance Score: 70%

Cardiovascular morbidity and mortality remain similar in two cohorts of patients with long-standing rheumatoid arthritis seen in 1978 and 1995 in Malmö, Sweden
Rheumatology, 10/30/09 Relevance Score: 70%

Frequency of migraine and the risk of cardiovascular disease for women: limited evidence of an association
Women's Health, 10/30/09 Relevance Score: 69%

Systemic lupus erythematosus and the risk of cardiovascular disease: Results from the Nurses Health Study
Arthritis Care and Research, 10/01/09 Relevance Score: 69%